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USP11

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq]

Full Name

ubiquitin specific peptidase 11

Function

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:28992046, PubMed:24724799).
Inhibits the degradation of target proteins by the proteasome (PubMed:12084015).
Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799).
Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889).
Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726).
Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937).
Promotes cell proliferation by deubiquitinating phosphorylated E2F1 (PubMed:28992046).

Biological Process

Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

Nucleus
Cytoplasm
Chromosome
Predominantly nuclear (PubMed:12084015, PubMed:15314155).
Associates with chromatin (PubMed:20601937, PubMed:20233726).

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Anti-USP11 antibodies

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Human Recombinant USP11, Active protein, GST Tag (V2LY-0526-LY7557)

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Target: USP11

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

Mouse Anti-USP11 Recombinant Antibody (CBT2141) (V2LY-0625-LY1933)

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Target: USP11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2141

Application*: WB, F

Mouse Anti-USP11 Recombinant Antibody (CBXU-067) (CBMAB-U0177-CQ)

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Target: USP11

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXU-067

Application*: WB, F

Mouse Anti-USP11 Recombinant Antibody (CBXU-046) (CBMAB-U0161-CQ)

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Target: USP11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXU-046

Application*: E, WB, F

Rabbit Anti-USP11 (Internal domain) Recombinant Antibody (CBXU-030) (CBMAB-U0146-CQ)

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Target: USP11

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXU-030

Application*: IC, IF, P, IP, WB

Rabbit Anti-USP11 Recombinant Antibody (CBXU-029) (CBMAB-U0145-CQ)

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Target: USP11

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXU-029

Application*: WB

Mouse Anti-USP11 (aa 201-300) Recombinant Antibody (8G5) (CBMAB-U0114-CQ)

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Target: USP11

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 8G5

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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