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Mouse Anti-USP11 (aa 201-300) Recombinant Antibody (8G5) (CBMAB-U0114-CQ)

This product is a mouse antibody that recognizes USP11 (aa 201-300). The antibody 8G5 can be used for immunoassay techniques such as: ELISA, WB.
See all USP11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8G5
Antibody Isotype
IgG2a, к
Application
ELISA, WB

Basic Information

Immunogen
USP11 (NP_004642, 201 a.a. - 300 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 201-300

Target

Full Name
ubiquitin specific peptidase 11
Introduction
This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin.
Entrez Gene ID
8237
UniProt ID
P51784
Alternative Names
UHX1
Function
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:28992046, PubMed:24724799).
Inhibits the degradation of target proteins by the proteasome (PubMed:12084015).
Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799).
Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889).
Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726).
Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937).
Promotes cell proliferation by deubiquitinating phosphorylated E2F1 (PubMed:28992046).
Biological Process
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Nucleus
Cytoplasm
Chromosome
Predominantly nuclear (PubMed:12084015, PubMed:15314155).
Associates with chromatin (PubMed:20601937, PubMed:20233726).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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