VSTM5

VSTM5 (V-Set And Transmembrane Domain Containing 5) is a Protein Coding gene.

Full Name

V-Set And Transmembrane Domain Containing 5

Function

Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain.

Biological Process

Biological Process filopodium assembly Source:UniProtKB
Biological Process positive regulation of excitatory synapse assembly Source:UniProtKB
Biological Process protein homooligomerization Source:UniProtKB
Biological Process ventral spinal cord development Source:Ensembl

Cellular Location

Cell membrane
Cell projection, dendrite
Cell projection, axon

Topology

Extracellular: 29-147
Helical: 148-168
Cytoplasmic: 169-200

PTM

N-glycosylated.