VTA1

C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 [PubMed 15644320]).

Full Name

Vesicle Trafficking 1

Function

Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity).
Involved in HIV-1 budding.

Biological Process

Biological Process ESCRT III complex disassembly Source:ParkinsonsUK-UCL1 Publication
Biological Process late endosome to vacuole transport via multivesicular body sorting pathway Source:GO_Central1 Publication
Biological Process macroautophagy Source:ParkinsonsUK-UCL1 Publication
Biological Process multivesicular body assembly Source:ParkinsonsUK-UCL1 Publication
Biological Process multivesicular body sorting pathway Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process viral budding Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Endosome membrane