Mouse Anti-VTA1 Recombinant Antibody (14G10) (CBMAB-V0085-YC)

Name: Mouse Anti-VTA1 Recombinant Antibody (14G10)
SKU: CBMAB-V0085-YC
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

14G10

Application

WB, FC, ELISA, ICC, IF

Immunogen

Recombinant human VTA1 (1-307aa) purified from E. coli

Specificity

Human

Antibody Isotype

IgG1, к

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-307

More Infomation

Target

Full Name

Vesicle Trafficking 1

Introduction

VTA1 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes.

Entrez Gene ID

51534

UniProt ID

Q9NP79

Alternative Names

Vesicle Trafficking 1; Vesicle (Multivesicular Body) Trafficking 1; Dopamine-Responsive Gene 1 Protein; LYST-Interacting Protein 5; SKD1-Binding Protein 1; C6orf55; DRG-1; SBP1; LIP5

Function

Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity).
Involved in HIV-1 budding.

Biological Process

Biological Process ESCRT III complex disassembly Source:ParkinsonsUK-UCL1 Publication
Biological Process late endosome to vacuole transport via multivesicular body sorting pathway Source:GO_Central1 Publication
Biological Process macroautophagy Source:ParkinsonsUK-UCL1 Publication
Biological Process multivesicular body assembly Source:ParkinsonsUK-UCL1 Publication
Biological Process multivesicular body sorting pathway Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process viral budding Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Endosome membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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