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Mouse Anti-VTA1 Recombinant Antibody (14G10) (CBMAB-V0085-YC)

Provided herein is a Mouse monoclonal antibody against Human VTA1. The antibody can be used for immunoassay techniques, such as WB, FC, ELISA, ICC, IF.
See all VTA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
14G10
Antibody Isotype
IgG1, к
Application
WB, FC, ELISA, ICC, IF

Basic Information

Immunogen
Recombinant human VTA1 (1-307aa) purified from E. coli
Specificity
Human
Antibody Isotype
IgG1, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-307

Target

Full Name
Vesicle Trafficking 1
Introduction
VTA1 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes.
Entrez Gene ID
51534
UniProt ID
Q9NP79
Alternative Names
Vesicle Trafficking 1; Vesicle (Multivesicular Body) Trafficking 1; Dopamine-Responsive Gene 1 Protein; LYST-Interacting Protein 5; SKD1-Binding Protein 1; C6orf55; DRG-1; SBP1; LIP5
Function
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity).
Involved in HIV-1 budding.
Biological Process
Biological Process ESCRT III complex disassembly Source:ParkinsonsUK-UCL1 Publication
Biological Process late endosome to vacuole transport via multivesicular body sorting pathway Source:GO_Central1 Publication
Biological Process macroautophagy Source:ParkinsonsUK-UCL1 Publication
Biological Process multivesicular body assembly Source:ParkinsonsUK-UCL1 Publication
Biological Process multivesicular body sorting pathway Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process viral budding Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Endosome membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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