WASF2

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Full Name

WASF2

Function

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.

Biological Process

Biological Process actin cytoskeleton organization Source:GO_Central1 Publication
Biological Process actin filament-based movement Source:Ensembl
Biological Process adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source:ProtInc1 Publication
Biological Process ameboidal-type cell migration Source:Ensembl
Biological Process angiogenesis Source:Ensembl
Biological Process endocytosis Source:Ensembl
Biological Process lamellipodium assembly Source:Ensembl
Biological Process lamellipodium morphogenesis Source:Ensembl
Biological Process megakaryocyte development Source:Ensembl
Biological Process negative regulation of stress fiber assembly Source:UniProtKB1 Publication
Biological Process positive regulation of Arp2/3 complex-mediated actin nucleation Source:GO_Central1 Publication
Biological Process positive regulation of lamellipodium assembly Source:UniProtKB2 Publications
Biological Process postsynaptic actin cytoskeleton organization Source:Ensembl
Biological Process Rac protein signal transduction Source:Ensembl

Cellular Location

Cytoplasm, cytoskeleton
Cell projection, lamellipodium
Basolateral cell membrane
At the interface between the lamellipodial actin meshwork and the membrane.