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Mouse Anti-WASF2 Recombinant Antibody (CBYY-1622) (CBMAB-1693-YY)

This product is mouse antibody that recognizes WASF2. The antibody CBYY-1622 can be used for immunoassay techniques such as: WB, IP, IF, ELISA
See all WASF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-1622
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WAS Protein Family Member 2
Introduction
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Entrez Gene ID
10163
UniProt ID
Q9Y6W5
Alternative Names
WAS Protein Family Member 2; Verprolin Homology Domain-Containing Protein 2; WASP Family Protein Member 2; Protein WAVE-2; WAVE2; Putative Wiskott-Aldrich Syndrome Protein Family Member 4; Wiskott-Aldrich Syndrome Protein Family Member 2; Suppressor Of Cyclic-AMP Receptor (WASP-Family);
Function
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Biological Process
Biological Process actin cytoskeleton organization Source:GO_Central1 Publication
Biological Process actin filament-based movement Source:Ensembl
Biological Process adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source:ProtInc1 Publication
Biological Process ameboidal-type cell migration Source:Ensembl
Biological Process angiogenesis Source:Ensembl
Biological Process endocytosis Source:Ensembl
Biological Process lamellipodium assembly Source:Ensembl
Biological Process lamellipodium morphogenesis Source:Ensembl
Biological Process megakaryocyte development Source:Ensembl
Biological Process negative regulation of stress fiber assembly Source:UniProtKB1 Publication
Biological Process positive regulation of Arp2/3 complex-mediated actin nucleation Source:GO_Central1 Publication
Biological Process positive regulation of lamellipodium assembly Source:UniProtKB2 Publications
Biological Process postsynaptic actin cytoskeleton organization Source:Ensembl
Biological Process Rac protein signal transduction Source:Ensembl
Cellular Location
Cytoplasm, cytoskeleton
Cell projection, lamellipodium
Basolateral cell membrane
At the interface between the lamellipodial actin meshwork and the membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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