WASF3

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]

Full Name

WAS Protein Family Member 3

Function

Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Biological Process

Biological Process actin cytoskeleton organization Source:GO_Central1 Publication
Biological Process actin filament polymerization Source:ProtInc1 Publication
Biological Process cytoskeleton organization Source:UniProtKB1 Publication
Biological Process lamellipodium assembly Source:Ensembl
Biological Process modification of postsynaptic actin cytoskeleton Source:Ensembl
Biological Process oligodendrocyte development Source:Ensembl
Biological Process positive regulation of Arp2/3 complex-mediated actin nucleation Source:GO_Central1 Publication
Biological Process positive regulation of myelination Source:Ensembl
Biological Process protein-containing complex assembly Source:ProtInc1 Publication
Biological Process regulation of cell shape Source:UniProtKB1 Publication

Cellular Location

Cytoplasm, cytoskeleton

PTM

Phosphorylation by ABL1 promotes lamellipodia formation and cell migration.