Mouse Anti-WASF3 Recombinant Antibody (CBYY-2091) (CBMAB-1701-YY)

Name: Mouse Anti-WASF3 Recombinant Antibody (CBYY-2091)
SKU: CBMAB-1701-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYY-2091

Application

WB, IP, IF, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

WAS Protein Family Member 3

Introduction

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]

Entrez Gene ID

10810

UniProt ID

O43915

Alternative Names

WAS Protein Family Member 3; Verprolin Homology Domain-Containing Protein 3; Protein WAVE-3; SCAR3; WAVE3; Wiskott-Aldrich Syndrome Protein Family Member 3;

Function

Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Biological Process

Biological Process actin cytoskeleton organization Source:GO_Central1 Publication
Biological Process actin filament polymerization Source:ProtInc1 Publication
Biological Process cytoskeleton organization Source:UniProtKB1 Publication
Biological Process lamellipodium assembly Source:Ensembl
Biological Process modification of postsynaptic actin cytoskeleton Source:Ensembl
Biological Process oligodendrocyte development Source:Ensembl
Biological Process positive regulation of Arp2/3 complex-mediated actin nucleation Source:GO_Central1 Publication
Biological Process positive regulation of myelination Source:Ensembl
Biological Process protein-containing complex assembly Source:ProtInc1 Publication
Biological Process regulation of cell shape Source:UniProtKB1 Publication

Cellular Location

Cytoplasm, cytoskeleton

PTM

Phosphorylation by ABL1 promotes lamellipodia formation and cell migration.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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