ZBTB20

This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]GeneCards Summary for ZBTB20 Gene ZBTB20 (Zinc Finger And BTB Domain Containing 20) is a Protein Coding gene. Diseases associated with ZBTB20 include Primrose Syndrome and Juvenile Pilocytic Astrocytoma. Gene Ontology (GO) annotations related to this gene include transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ZBTB45.May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).

zinc finger and BTB domain containing 20

May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661).
Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).

Biological Process cellular response to glucose stimulus Source:UniProtKB
Biological Process lipid homeostasis Source:UniProtKB
Biological Process negative regulation of gene expression Source:Ensembl
Biological Process positive regulation of glycolytic process Source:UniProtKB
Biological Process positive regulation of interferon-beta production Source:Ensembl
Biological Process positive regulation of interleukin-6 production Source:Ensembl
Biological Process positive regulation of lipid biosynthetic process Source:UniProtKB
Biological Process positive regulation of tumor necrosis factor production Source:Ensembl
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication

Nucleus

Primrose syndrome (PRIMS):
A disease characterized by macrocephaly, intellectual disability, disturbed behavior, dysmorphic facial features, ectopic calcifications, large calcified ear auricles, and progressive muscle wasting.

Sumoylated with SUMO1.