ZBTB38

The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types.

Full Name

zinc finger and BTB domain containing 38

Function

Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688).
Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).
Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).

Biological Process

Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB2 Publications
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB
Biological Process regulation of DNA replication Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:GO_Central1 Publication

Cellular Location

Nucleus
Chromosome
Localizes to chromocenters.

PTM

Ubiquitinated by RBBP6; leading to its degradation by the proteasome.