Mouse Anti-ZBTB38 Recombinant Antibody (2C6) (CBMAB-Z0096-WJ)

Name: Mouse Anti-ZBTB38 Recombinant Antibody (2C6)
SKU: CBMAB-Z0096-WJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

2C6

Application

IHC, WB

Immunogen

Full length recombinant protein of human ACSS2 produced in HEK293T cells.

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

More Infomation

Target

Full Name

zinc finger and BTB domain containing 38

Introduction

ZBTB38 (Zinc Finger And BTB Domain Containing 38) is a Protein Coding gene encoded the protein which is a zinc finger transcriptional activator that binds methylated DNA.. Diseases associated with ZBTB38 include Stature Quantitative Trait Locus 10 and Kuru. An important paralog of this gene is ZBTB4.

Entrez Gene ID

253461

UniProt ID

Q8NAP3

Alternative Names

CIBZ; ZNF921; PPP1R171

Function

Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688).
Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).
Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).

Biological Process

Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB2 Publications
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB
Biological Process regulation of DNA replication Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:GO_Central1 Publication

Cellular Location

Nucleus
Chromosome
Localizes to chromocenters.

PTM

Ubiquitinated by RBBP6; leading to its degradation by the proteasome.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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