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Mouse Anti-ZBTB38 Recombinant Antibody (2C6) (CBMAB-Z0096-WJ)

This product is a mouse antibody that recognizes ZBTB38. The antibody 2C6 can be used for immunoassay techniques such as: IHC, WB.
See all ZBTB38 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C6
Antibody Isotype
IgG2b
Application
IHC, WB

Basic Information

Immunogen
Full length recombinant protein of human ACSS2 produced in HEK293T cells.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL

Target

Full Name
zinc finger and BTB domain containing 38
Introduction
ZBTB38 (Zinc Finger And BTB Domain Containing 38) is a Protein Coding gene encoded the protein which is a zinc finger transcriptional activator that binds methylated DNA.. Diseases associated with ZBTB38 include Stature Quantitative Trait Locus 10 and Kuru. An important paralog of this gene is ZBTB4.
Entrez Gene ID
253461
UniProt ID
Q8NAP3
Alternative Names
CIBZ; ZNF921; PPP1R171
Function
Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688).
Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).
Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).
Biological Process
Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB2 Publications
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB
Biological Process regulation of DNA replication Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:GO_Central1 Publication
Cellular Location
Nucleus
Chromosome
Localizes to chromocenters.
PTM
Ubiquitinated by RBBP6; leading to its degradation by the proteasome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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