Rabbit Anti-CD93 Recombinant Antibody (4) (CBMAB-C1509-LY)

Name: Rabbit Anti-CD93 Recombinant Antibody (4)
SKU: CBMAB-C1509-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

Application

ELISA

Immunogen

Recombinant Human CD93 / C1qR Protein.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CD93 molecule

Introduction

CD93 (CD93 Molecule) is a Protein Coding gene. Among its related pathways are Innate Immune System and Immune response Lectin induced complement pathway.
Gene Ontology (GO) annotations related to this gene include calcium ion binding and carbohydrate binding. An important paralog of this gene is THBD.

Entrez Gene ID

22918

UniProt ID

Q9NPY3

Alternative Names

CD93 Molecule; CD93 Antigen; Complement Component 1 Q Subcomponent Receptor 1; Matrix-Remodeling-Associated Protein 4; Matrix-Remodelling Associated 4; C1q/MBL/SPA Receptor; C1qR(P); C1qRP; C1QR1;

Function

Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

Biological Process

Cell-cell adhesion Source: UniProtKB
Macrophage activation Source: UniProtKB
Neutrophil degranulation Source: Reactome
Phagocytosis Source: UniProtKB
Viral process Source: UniProtKB-KW

Cellular Location

Membrane

Topology

Extracellular: 24-580
Helical: 581-601
Cytoplasmic: 602-652

PTM

N- and O-glycosylated.

Sun, Y., Chen, W., Torphy, R. J., Yao, S., Zhu, G., Lin, R., ... & Zhu, Y. (2021). Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Science translational medicine, 13(604), eabc8922.

Barbera, S., Raucci, L., Lugano, R., Tosi, G. M., Dimberg, A., Santucci, A., ... & Orlandini, M. (2021). CD93 Signaling via Rho Proteins Drives Cytoskeletal Remodeling in Spreading Endothelial Cells. International Journal of Molecular Sciences, 22(22), 12417.

Barbera, S., Lugano, R., Pedalina, A., Mongiat, M., Santucci, A., Tosi, G. M., ... & Orlandini, M. (2021). The C-type lectin CD93 controls endothelial cell migration via activation of the Rho family of small GTPases. Matrix Biology.

Kinstrie, R., Horne, G. A., Morrison, H., Irvine, D., Munje, C., Castañeda, E. G., ... & Copland, M. (2020). CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy. Leukemia, 34(6), 1613-1625.

Tosi, G. M., Neri, G., Barbera, S., Mundo, L., Parolini, B., Lazzi, S., ... & Orlandini, M. (2020). The Binding of CD93 to Multimerin-2 Promotes Choroidal Neovascularization. Investigative ophthalmology & visual science, 61(8), 30-30.

Barbera, S., Nardi, F., Elia, I., Realini, G., Lugano, R., Santucci, A., ... & Orlandini, M. (2019). The small GTPase Rab5c is a key regulator of trafficking of the CD93/Multimerin-2/β1 integrin complex in endothelial cell adhesion and migration. Cell Communication and Signaling, 17(1), 1-15.

Lugano, R., Vemuri, K., Yu, D., Bergqvist, M., Smits, A., Essand, M., ... & Dimberg, A. (2018). CD93 promotes β 1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. The Journal of clinical investigation, 128(8), 3280-3297.

Griffiths, M. R., Botto, M., Morgan, B. P., Neal, J. W., & Gasque, P. (2018). CD93 regulates central nervous system inflammation in two mouse models of autoimmune encephalomyelitis. Immunology, 155(3), 346-355.

Galvagni, F., Nardi, F., Spiga, O., Trezza, A., Tarticchio, G., Pellicani, R., ... & Orlandini, M. (2017). Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium. Matrix Biology, 64, 112-127.

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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