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Mouse Anti-C1QC Recombinant Antibody (13A17) (CBMAB-C1122-CN)

This product is a Mouse antibody that recognizes C1QC. The antibody 13A17 can be used for immunoassay techniques such as: ELISA, WB, IP, FC.
See all C1QC antibodies

Summary

Host Animal
Mouse
Specificity
Hamster, Human, Rat
Clone
13A17
Antibody Isotype
IgG1
Application
ELISA, WB, IP, FC

Basic Information

Immunogen
Recognizes epitopes situated within the NH2-terminal stretch of gC1q-R corresponding to aa 76-93. This clone recognizes the putative C1q binding site and reacts with the mature form, but has poor or no reactivity with the truncated form, lacking aa 74-95. Species Crossreactivity: rat and syrian hamster
Specificity
Hamster, Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% BSA

Target

Full Name
complement C1q C chain
Introduction
This gene encodes the C-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.
Entrez Gene ID
Human714
Hamster101825510
Rat362634
UniProt ID
HumanP02747
HamsterA0A1U7R4U0
RatP31722
Alternative Names
C1QG; C1Q-C
Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Biological Process
Complement activation Source: Reactome
Complement activation, classical pathway Source: Reactome
Immune response Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Negative regulation of granulocyte differentiation Source: BHF-UCL
Negative regulation of macrophage differentiation Source: BHF-UCL
Regulation of complement activation Source: Reactome
Synapse pruning Source: ARUK-UCL
Cellular Location
Secreted
Involvement in disease
Complement component C1q deficiency (C1QD): A disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
PTM
O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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