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C1QC

This gene encodes the C-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.
Full Name
complement C1q C chain
Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Biological Process
Complement activation Source: Reactome
Complement activation, classical pathway Source: Reactome
Immune response Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Negative regulation of granulocyte differentiation Source: BHF-UCL
Negative regulation of macrophage differentiation Source: BHF-UCL
Regulation of complement activation Source: Reactome
Synapse pruning Source: ARUK-UCL
Cellular Location
Secreted
Involvement in disease
Complement component C1q deficiency (C1QD): A disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
PTM
O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.

Anti-C1QC antibodies

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Rabbit Anti-C1QC Recombinant Antibody (EPR2984Y) (CBMAB-1239-CN)

Datasheet SDS
Target: C1QC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EPR2984Y
Application*: F, IC, P, IP, WB

Mouse Anti-C1QC Recombinant Antibody (CBXC-2493) (CBMAB-C3270-CQ)

Datasheet SDS
Target: C1QC
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBXC-2493
Application*: E, WB

Mouse Anti-C1QC Recombinant Antibody (CBFYC-0601) (CBMAB-C0655-FY)

Datasheet SDS
Target: C1QC
Host: Mouse
Specificity: Human
Clone: CBFYC-0601
Application*: IP, E

Mouse Anti-C1QC Recombinant Antibody (CBFYC-0600) (CBMAB-C0654-FY)

Datasheet SDS
Target: C1QC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0600
Application*: E, FN, WB

Rabbit Anti-C1QC Recombinant Antibody (EG435) (CBMAB-EN494-LY)

Datasheet SDS
Target: C1QC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG435
Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Mouse Anti-C1QC Recombinant Antibody (115) (CBMAB-AP707LY)

Datasheet SDS
Target: C1QC
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 115
Application*: ELISA, WB

Mouse Anti-C1QC Recombinant Antibody (13A17) (CBMAB-C1122-CN)

Datasheet SDS
Target: C1QC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Hamster, Human, Rat
Clone: 13A17
Application*: E, WB, IP, FC

Mouse Anti-C1QC Recombinant Antibody (1.T.23) (CBMAB-C1121-CN)

Datasheet SDS
Target: C1QC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1.T.23
Application*: E, FC, IF, WB

Mouse Anti-C1QC Recombinant Antibody (2Q229) (CBMAB-C12805-LY)

Datasheet SDS
Target: C1QC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 2Q229
Application*: E, WB, IP, F

Rat Anti-C1QC Recombinant Antibody (7H8) (CBMAB-C8856-LY)

Datasheet SDS
Target: C1QC
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 7H8
Application*: E, FN, IF, C

Mouse Anti-C1QC Recombinant Antibody (3R9/2) (CBMAB-C6404-LY)

Datasheet SDS
Target: C1QC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3R9/2
Application*: E, F, IF, C, WB

Mouse Anti-C1QC Recombinant Antibody (242G3) (CBMAB-C4469-LY)

Datasheet SDS
Target: C1QC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 242G3
Application*: E, FN, WB

Mouse Anti-C1QC Recombinant Antibody (1A4) (CBMAB-C3540-LY)

Datasheet SDS
Target: C1QC
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1A4
Application*: IP, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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