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Mouse Anti-C1QC Recombinant Antibody (CBXC-2493) (CBMAB-C3270-CQ)

This product is a mouse antibody that recognizes C1QC. The antibody CBXC-2493 can be used for immunoassay techniques such as: ELISA, WB.
See all C1QC antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2493
Antibody Isotype
IgM
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
complement C1q C chain
Introduction
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene.
Entrez Gene ID
714
UniProt ID
P02747
Alternative Names
C1Q-C; C1QG
Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Biological Process
Complement activation Source: Reactome
Complement activation, classical pathway Source: Reactome
Immune response Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Negative regulation of granulocyte differentiation Source: BHF-UCL
Negative regulation of macrophage differentiation Source: BHF-UCL
Regulation of complement activation Source: Reactome
Synapse pruning Source: ARUK-UCL
Cellular Location
Secreted
Involvement in disease
Complement component C1q deficiency (C1QD): A disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
PTM
O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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