Sign in or Register   Sign in or Register
  |  

Mouse Anti-C6 Recombinant Antibody (13H5) (CBMAB-C2911-LY)

This product is antibody recognizes C6. The antibody 13H5 immunoassay techniques such as: WB, IP, ELISA.
See all C6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13H5
Antibody Isotype
IgG2b
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
complement C6
Entrez Gene ID
729
UniProt ID
P13671
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Biological Process
Complement activation Source: Reactome
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
In utero embryonic development Source: Ensembl
Regulation of complement activation Source: Reactome
Cellular Location
Secreted
Involvement in disease
Complement component 6 deficiency (C6D): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
PTM
All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.

Lin, K., Zhang, L., Kong, M., Yang, M., Chen, Y., Poptic, E., ... & Lin, F. (2020). Development of an anti-human complement C6 monoclonal antibody that inhibits the assembly of membrane attack complexes. Blood advances, 4(9), 2049-2057.

Fattahi, F., Grailer, J. J., Parlett, M., Lu, H., Malan, E. A., Abe, E., ... & Ward, P. A. (2020). Requirement of complement c6 for intact innate immune responses in mice. The Journal of Immunology, 205(1), 251-260.

Karadadas, E., Hortu, I., Ak, H., Ergenoglu, A. M., Karadadas, N., & Aydin, H. H. (2020). Evaluation of complement system proteins C3a, C5a and C6 in patients of endometriosis. Clinical biochemistry, 81, 15-19.

Bae, J. Y., Ham, A., Choi, H. J., & Kim, C. J. (2020). Recurrent meningococcal meningitis with complement 6 (C6) deficiency: A case report. Medicine, 99(21).

Hatke, A. L., Green, D. R., Stasiak, K., & Marconi, R. T. (2020). Antibody profiling of a Borreliella burgdorferi (Lyme disease) C6 antibody positive, symptomatic Rottweiler and her pups. The Veterinary Journal, 262, 105504.

Rosenfield, L., Cvetkovic, A., Woodward, K., & Quirt, J. (2018). Late presentation of subtotal C6 deficiency in a patient with recurrent Neisseria meningitides infections. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology, 120(4), 432-433.

Liyanage, D. S., Omeka, W. K. M., Godahewa, G. I., Lee, S., Nam, B. H., & Lee, J. (2018). Membrane attack complex-associated molecules from redlip mullet (Liza haematocheila): Molecular characterization and transcriptional evidence of C6, C7, C8β, and C9 in innate immunity. Fish & shellfish immunology, 81, 1-9.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-C6 Recombinant Antibody (13H5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare