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Mouse Anti-C6 Recombinant Antibody (CBFYA-0197) (CBMAB-X0278-FY)

This product is mouse antibody that recognizes C6. The antibody CBFYA-0197 can be used for immunoassay techniques such as: FC, FuncS, Immunoassay, IF, IP, IHC-P, WB.
See all C6 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rabbit
Clone
CBFYA-0197
Antibody Isotype
IgG1
Application
FC, FuncS, Immunoassay, IF, IP, IHC-P, WB

Basic Information

Immunogen
Human C6
Specificity
Human, Rabbit
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% BSA
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
complement C6
Introduction
This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis.
Entrez Gene ID
Human729
Rabbit100359210
UniProt ID
HumanP13671
RabbitG1SGF8
Alternative Names
C6
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Biological Process
Complement activation Source: Reactome
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
In utero embryonic development Source: Ensembl
Regulation of complement activation Source: Reactome
Cellular Location
Secreted
Involvement in disease
Complement component 6 deficiency (C6D): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
PTM
All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.

Lin, K., Zhang, L., Kong, M., Yang, M., Chen, Y., Poptic, E., ... & Lin, F. (2020). Development of an anti-human complement C6 monoclonal antibody that inhibits the assembly of membrane attack complexes. Blood advances, 4(9), 2049-2057.

Fattahi, F., Grailer, J. J., Parlett, M., Lu, H., Malan, E. A., Abe, E., ... & Ward, P. A. (2020). Requirement of complement c6 for intact innate immune responses in mice. The Journal of Immunology, 205(1), 251-260.

Karadadas, E., Hortu, I., Ak, H., Ergenoglu, A. M., Karadadas, N., & Aydin, H. H. (2020). Evaluation of complement system proteins C3a, C5a and C6 in patients of endometriosis. Clinical biochemistry, 81, 15-19.

Bae, J. Y., Ham, A., Choi, H. J., & Kim, C. J. (2020). Recurrent meningococcal meningitis with complement 6 (C6) deficiency: A case report. Medicine, 99(21).

Hatke, A. L., Green, D. R., Stasiak, K., & Marconi, R. T. (2020). Antibody profiling of a Borreliella burgdorferi (Lyme disease) C6 antibody positive, symptomatic Rottweiler and her pups. The Veterinary Journal, 262, 105504.

Rosenfield, L., Cvetkovic, A., Woodward, K., & Quirt, J. (2018). Late presentation of subtotal C6 deficiency in a patient with recurrent Neisseria meningitides infections. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology, 120(4), 432-433.

Liyanage, D. S., Omeka, W. K. M., Godahewa, G. I., Lee, S., Nam, B. H., & Lee, J. (2018). Membrane attack complex-associated molecules from redlip mullet (Liza haematocheila): Molecular characterization and transcriptional evidence of C6, C7, C8β, and C9 in innate immunity. Fish & shellfish immunology, 81, 1-9.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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