Mouse Anti-C6 Recombinant Antibody (CBFYC-0667) (CBMAB-C0721-FY)
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Datasheet
Target
Q & As
Review & reward
Protocols
Associated Products
Basic Information
Host Animal
Mouse
Clone
CBFYC-0667
Application
WB, IP, IF, E
Immunogen
Amino acids 118-360 mapping near the N-terminus of C6 of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
| Application | Note |
| WB | 1:100-1:1,000 |
| IP | 1-2 µg per 100-500 µg of total protein (1 ml of cell lysate) |
| IF(ICC) | 1:50-1:500 |
| ELISA | 1:100-1:1,000 |
Formulations & Storage [For reference only, actual COA shall prevail!]
Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation
Target
Full Name
complement C6
Introduction
This gene encodes a component of the complement cascade.
Entrez Gene ID
UniProt ID
Alternative Names
Complement C6 (Complement Component 6, C6)
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Biological Process
Complement activation Source: Reactome
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
In utero embryonic development Source: Ensembl
Regulation of complement activation Source: Reactome
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
In utero embryonic development Source: Ensembl
Regulation of complement activation Source: Reactome
Cellular Location
Secreted
Involvement in disease
Complement component 6 deficiency (C6D): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
PTM
All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
For research use only. Not intended for any clinical use.
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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