Human Recombinant C6 protein, His Tag (V2LY-0526-LY2460)

Name: Human Recombinant C6 protein, His Tag
SKU: V2LY-0526-LY2460
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant C6 protein, His Tag consist of Amino Acid: 1-934 and predicts a molecular mass of 104 kDa.

Molecule Mass

104 kDa

Sequence

Amino Acid: 1-934

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

complement C6

Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

Biological Process

Complement activation Source: Reactome
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
In utero embryonic development Source: Ensembl
Regulation of complement activation Source: Reactome

Cellular Location

Secreted

Involvement in disease

Complement component 6 deficiency (C6D): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

PTM

All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.

Lin, K., Zhang, L., Kong, M., Yang, M., Chen, Y., Poptic, E., ... & Lin, F. (2020). Development of an anti-human complement C6 monoclonal antibody that inhibits the assembly of membrane attack complexes. Blood advances, 4(9), 2049-2057.

Fattahi, F., Grailer, J. J., Parlett, M., Lu, H., Malan, E. A., Abe, E., ... & Ward, P. A. (2020). Requirement of complement c6 for intact innate immune responses in mice. The Journal of Immunology, 205(1), 251-260.

Karadadas, E., Hortu, I., Ak, H., Ergenoglu, A. M., Karadadas, N., & Aydin, H. H. (2020). Evaluation of complement system proteins C3a, C5a and C6 in patients of endometriosis. Clinical biochemistry, 81, 15-19.

Bae, J. Y., Ham, A., Choi, H. J., & Kim, C. J. (2020). Recurrent meningococcal meningitis with complement 6 (C6) deficiency: A case report. Medicine, 99(21).

Hatke, A. L., Green, D. R., Stasiak, K., & Marconi, R. T. (2020). Antibody profiling of a Borreliella burgdorferi (Lyme disease) C6 antibody positive, symptomatic Rottweiler and her pups. The Veterinary Journal, 262, 105504.

Rosenfield, L., Cvetkovic, A., Woodward, K., & Quirt, J. (2018). Late presentation of subtotal C6 deficiency in a patient with recurrent Neisseria meningitides infections. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology, 120(4), 432-433.

Liyanage, D. S., Omeka, W. K. M., Godahewa, G. I., Lee, S., Nam, B. H., & Lee, J. (2018). Membrane attack complex-associated molecules from redlip mullet (Liza haematocheila): Molecular characterization and transcriptional evidence of C6, C7, C8β, and C9 in innate immunity. Fish & shellfish immunology, 81, 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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