C6

This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.

Full Name

complement C6

Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

Biological Process

Complement activation Source: Reactome
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
In utero embryonic development Source: Ensembl
Regulation of complement activation Source: Reactome

Cellular Location

Secreted

Involvement in disease

Complement component 6 deficiency (C6D): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

PTM

All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.

Anti-C6 antibodies

Mouse Anti-C6 Recombinant Antibody (3G11) (CBMAB-C6106-LY)

Datasheet

SDS

Target: C6

Host: Mouse

Antibody Isotype: IgG1, ĸ

Specificity: Rat, Mouse

Clone: 3G11

Application*: WB

Rabbit Anti-C6 Recombinant Antibody (037) (CBMAB-C1727-LY)

Datasheet

SDS

Target: C6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 037

Application*: E

Mouse Anti-C6 Recombinant Antibody (CBFYC-0668) (CBMAB-C0722-FY)

Datasheet

SDS

Target: C6

Host: Mouse

Antibody Isotype: IgG2b, ĸ

Specificity: Human

Clone: CBFYC-0668

Application*: WB, IP, IF, E

Mouse Anti-C6 Recombinant Antibody (CBFYC-0667) (CBMAB-C0721-FY)

Datasheet

SDS

Target: C6

Host: Mouse

Antibody Isotype: IgG1, ĸ

Specificity: Human

Clone: CBFYC-0667

Application*: WB, IP, IF, E

Mouse Anti-C6 Recombinant Antibody (CBYY-C0822) (CBMAB-C2258-YY)

Datasheet

SDS

Target: C6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C0822

Application*: E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)