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C6

This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.
Full Name
complement C6
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Biological Process
Complement activation Source: Reactome
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
In utero embryonic development Source: Ensembl
Regulation of complement activation Source: Reactome
Cellular Location
Secreted
Involvement in disease
Complement component 6 deficiency (C6D): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
PTM
All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.
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Anti-C6 antibodies

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Rabbit Anti-C6 Recombinant Antibody (037) (CBMAB-C1727-LY)

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Target: C6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 037
Application*: E
Datasheet SDS

Mouse Anti-C6 Recombinant Antibody (CBYY-C0822) (CBMAB-C2258-YY)

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Target: C6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0822
Application*: E
Datasheet SDS

Mouse Anti-C6 Recombinant Antibody (3G11) (CBMAB-C6106-LY)

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Target: C6
Host: Mouse
Antibody Isotype: IgG1, ĸ
Specificity: Rat, Mouse
Clone: 3G11
Application*: WB
Datasheet SDS

Mouse Anti-C6 Recombinant Antibody (CBFYC-0668) (CBMAB-C0722-FY)

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Target: C6
Host: Mouse
Antibody Isotype: IgG2b, ĸ
Specificity: Human
Clone: CBFYC-0668
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-C6 Recombinant Antibody (CBFYC-0667) (CBMAB-C0721-FY)

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Target: C6
Host: Mouse
Antibody Isotype: IgG1, ĸ
Specificity: Human
Clone: CBFYC-0667
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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