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Mouse Anti-CADM3 Recombinant Antibody (MM0762-13V23) (CBMAB-1267-CN)

This product is a mouse antibody that recognizes CADM3 of human. The antibody MM0762-13V23 can be used for immunoassay techniques such as: IHC-P, WB.
See all CADM3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
MM0762-13V23
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Immunogen
Recombinant fragment corresponding to Human CADM3 aa. 21-328.
Sequence: PGGANLSQDDSQPWTSDETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRDNRIQLVTSTPHELSISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKSSLREKDTATLNCQSSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPPHPREGQKLLLHCEGRGNPVPQQYLWEKEGSVPPLKMTQESALIFPFLNKSDSGTYGCTATSNMGSYKAYYTLNVNDPSPVPSSSST
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100% PBS
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cell Adhesion Molecule 3
Introduction
The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. Involved in the cell-cell adhesion. Its interaction with EPB41L1 may regulate structure or function of cell-cell junctions.
Entrez Gene ID
57863
UniProt ID
Q8N126
Alternative Names
BIgR; NECL1; TSLL1; IGSF4B; Necl-1; synCAM3
Function
Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).
Biological Process
Adherens junction organization Source: Reactome
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: HGNC-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: HGNC-UCL
Cellular Location
Cell membrane; Cell junction
Topology
Extracellular: 25-330 aa
Helical: 331-351 aa
Cytoplasmic: 352-398 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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