CADM3
The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016]
Full Name
Cell Adhesion Molecule 3
Function
Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).
Biological Process
Adherens junction organization Source: Reactome
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: HGNC-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: HGNC-UCL
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: HGNC-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: HGNC-UCL
Cellular Location
Cell membrane; Cell junction
Topology
Extracellular: 25-330 aa
Helical: 331-351 aa
Cytoplasmic: 352-398 aa
Helical: 331-351 aa
Cytoplasmic: 352-398 aa
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Anti-CADM3 antibodies
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Target: CADM3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 3
Application*: E
Target: CADM3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 024
Application*: E
Target: CADM3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-328
Tag: His Tag
Target: CADM3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-328
Tag: hFc Tag
Target: CADM3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-328
Tag: His Tag
Target: CADM3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-330
Tag: His Tag
Target: CADM3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-0727
Application*: E
Target: CADM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0724
Application*: WB, IH
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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