Human Recombinant CADM3 protein, His Tag (V2LY-0526-LY2503)

Name: Human Recombinant CADM3 protein, His Tag
SKU: V2LY-0526-LY2503
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CADM3 protein, His Tag consist of Amino Acid: 1-330 and predicts a molecular mass of 35.1 kDa.

Molecule Mass

35.1 kDa

Sequence

Amino Acid: 1-330

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Cell Adhesion Molecule 3

Function

Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).

Biological Process

Adherens junction organization Source: Reactome
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: HGNC-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: HGNC-UCL

Cellular Location

Cell membrane; Cell junction

Topology

Extracellular: 25-330 aa
Helical: 331-351 aa
Cytoplasmic: 352-398 aa

Sukhanov, N., Vainshtein, A., Eshed-Eisenbach, Y., & Peles, E. (2021). Differential Contribution of Cadm1–Cadm3 Cell Adhesion Molecules to Peripheral Myelinated Axons. Journal of Neuroscience, 41(7), 1393-1400.

Rebelo, A. P., Cortese, A., Abraham, A., Eshed-Eisenbach, Y., Shner, G., Vainshtein, A., ... & Zuchner, S. (2021). A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement. Brain, 144(4), 1197-1213.

Miao, X., Wang, Z., Chen, B., Chen, Y., Wang, X., Jiang, L., ... & Zhang, W. (2018). miR-140-5p suppresses retinoblastoma cell proliferation, migration, and invasion by targeting CEMIP and CADM3. Cellular and Molecular Biology, 64(6), 42-47.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant CADM3 protein, His Tag (CAT#: V2LY-0526-LY7898)

Rat Recombinant CADM3 protein, hFc Tag (CAT#: V2LY-0526-LY9193)

Rat Recombinant CADM3 protein, His Tag (CAT#: V2LY-0526-LY9194)

Related Products

Rat Recombinant CADM3 protein, His Tag (CAT#: V2LY-0526-LY9194)

Mouse Recombinant CADM3 protein, His Tag (CAT#: V2LY-0526-LY7898)

Rabbit Anti-CADM3 Recombinant Antibody (CBFYC-0727) (CAT#: CBMAB-C0782-FY)

Rabbit Anti-CADM3 Recombinant Antibody (3) (CAT#: CBMAB-C5424-LY)

Rabbit Anti-CADM3 Recombinant Antibody (024) (CAT#: CBMAB-C1684-LY)

Mouse Anti-CADM3 Recombinant Antibody (CBYY-I0724) (CAT#: CBMAB-I1616-YY)

Rat Recombinant CADM3 protein, hFc Tag (CAT#: V2LY-0526-LY9193)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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