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Mouse Anti-CBX1 Recombinant Antibody (1MOD-1A9) (CBMAB-C4292-LY)

This product is antibody recognizes CBX1. The antibody 1MOD-1A9 immunoassay techniques such as: IHC-P.
See all CBX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Pig
Clone
1MOD-1A9
Antibody Isotype
IgG1
Application
IHC-P

Basic Information

Specificity
Human, Mouse, Pig
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chromobox 1
Introduction
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human10951
Mouse12412
Pig100520403
UniProt ID
HumanP83916
MouseP83917
PigF1RWH1
Function
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
Biological Process
Cellular response to DNA damage stimulus Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: Ensembl
Viral life cycle Source: Reactome
Cellular Location
Nucleus. Unassociated with chromosomes during mitosis.
PTM
Not phosphorylated.
Ubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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