CBX1

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Full Name
Chromobox 1
Function
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
Biological Process
Cellular response to DNA damage stimulus Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: Ensembl
Viral life cycle Source: Reactome
Cellular Location
Nucleus. Unassociated with chromosomes during mitosis.
PTM
Not phosphorylated.
Ubiquitinated.
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Anti-CBX1 antibodies

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Mouse Anti-CBX1 Recombinant Antibody (CBT266) (V2LY-0625-LY3653)

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Target: CBX1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBT266
Application*: WB, IF, IC, F, E
Datasheet SDS

Mouse Anti-CBX1 Recombinant Antibody (CBT733) (V2LY-0625-LY3320)

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Target: CBX1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Chicken, Dog, Pig
Clone: CBT733
Application*: WB
Datasheet SDS

Mouse Anti-CBX1 Recombinant Antibody (CBT4477) (V2LY-0625-LY304)

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Target: CBX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4477
Application*: IH
Datasheet SDS

Mouse Anti-CBX1 Recombinant Antibody (CBT2148) (V2LY-0625-LY303)

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Target: CBX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2148
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-CBX1 Recombinant Antibody (CBT3914) (V2LY-0625-LY2355)

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Target: CBX1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBT3914
Application*: WB, IC, F
Datasheet SDS

Rat Anti-CBX1 Recombinant Antibody (MAC353) (CBMAB-C9780-LY)

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Target: CBX1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: MAC353
Application*: WB, IP, IC/IF
Datasheet SDS

Mouse Anti-CBX1 Recombinant Antibody (4E12) (CBMAB-C6844-LY)

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Target: CBX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 4E12
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-CBX1 Recombinant Antibody (CBFYH-0040) (CBMAB-H0854-FY)

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Target: CBX1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBFYH-0040
Application*: E, F, IF, WB
Datasheet SDS

Mouse Anti-CBX1 Recombinant Antibody (4D7B8) (CBMAB-H0853-FY)

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Target: CBX1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 4D7B8
Application*: WB, IP, IF, P, F, E
Datasheet SDS

Rabbit Anti-CBX1 Recombinant Antibody (D2F2) (CBMAB-H0017-FY)

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Target: CBX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D2F2
Application*: WB, IP, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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