Mouse Anti-CBX1 Recombinant Antibody (CBT266) (V2LY-0625-LY3653)

Name: Mouse Anti-CBX1 Recombinant Antibody (CBT266)
SKU: V2LY-0625-LY3653
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Monkey

Clone

CBT266

Antibody Isotype

IgG

Application

WB, IF, ICC, FC, ELISA

Basic Information

Immunogen

Purified recombinant fragment of human CBX1 expressed in E. Coli.

Host Species

Mouse

Specificity

Human, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:10,000
FC	1:200-1:400
IF	1:200-1:1,000
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Buffer

BSA, Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Chromobox 1

Entrez Gene ID

10951

UniProt ID

P83916

Function

Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.

Biological Process

Cellular response to DNA damage stimulus Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: Ensembl
Viral life cycle Source: Reactome

Cellular Location

Nucleus. Unassociated with chromosomes during mitosis.

PTM

Not phosphorylated.
Ubiquitinated.

More Infomation

References

Hu, A., Zhang, Y., Zhao, X., Li, J., & Ying, Y. (2019). CBX1 is a direct target of miR-205-5p and contributes to the progression of pituitary tumor. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 74(3), 154-156.

Wang, H., Zhang, X. M., Tomiyoshi, G. O., Nakamura, R., Shinmen, N., Kuroda, H., ... & Hiwasa, T. (2018). Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction. Oncotarget, 9(5), 5600.

Yang, Y. F., Pan, Y. H., Tian, Q. H., Wu, D. C., & Su, S. G. (2018). CBX1 indicates poor outcomes and exerts oncogenic activity in hepatocellular carcinoma. Translational oncology, 11(5), 1110-1118.

Ning, G., Huang, Y. L., Zhen, L. M., Xu, W. X., Jiao, Q., Yang, F. J., ... & Peng, L. (2018). Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients. Aging (Albany NY), 10(11), 3450.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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