Rat Anti-CBX1 Recombinant Antibody (MAC353) (CBMAB-C9780-LY)

Name: Rat Anti-CBX1 Recombinant Antibody (MAC353)
SKU: CBMAB-C9780-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

MAC353

Application

WB, IP, ICC/IF

Immunogen

C-terminus of HP1β of mouse origin.

Host Species

Rat

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Preservative

< 0.1% sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Chromobox 1

Introduction

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	10951
Mouse	12412

UniProt ID

Human	P83916
Mouse	P83917

Function

Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.

Biological Process

Cellular response to DNA damage stimulus Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: Ensembl
Viral life cycle Source: Reactome

Cellular Location

Nucleus. Unassociated with chromosomes during mitosis.

PTM

Not phosphorylated.
Ubiquitinated.

Hu, A., Zhang, Y., Zhao, X., Li, J., & Ying, Y. (2019). CBX1 is a direct target of miR-205-5p and contributes to the progression of pituitary tumor. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 74(3), 154-156.

Wang, H., Zhang, X. M., Tomiyoshi, G. O., Nakamura, R., Shinmen, N., Kuroda, H., ... & Hiwasa, T. (2018). Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction. Oncotarget, 9(5), 5600.

Yang, Y. F., Pan, Y. H., Tian, Q. H., Wu, D. C., & Su, S. G. (2018). CBX1 indicates poor outcomes and exerts oncogenic activity in hepatocellular carcinoma. Translational oncology, 11(5), 1110-1118.

Ning, G., Huang, Y. L., Zhen, L. M., Xu, W. X., Jiao, Q., Yang, F. J., ... & Peng, L. (2018). Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients. Aging (Albany NY), 10(11), 3450.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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