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Mouse Anti-CBX1 Recombinant Antibody (CBFYH-0040) (CBMAB-H0854-FY)


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Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
CBFYH-0040
Antibody Isotype
IgG
Application
ELISA, FC, IF, WB

Basic Information

Immunogen
Purified recombinant fragment of human CBX1 expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
FC1:200-1:400
IF(ICC)1:200-1:1,000
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.5% BSA, 50%glycerol
Preservative
0.03% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 2-99

Target

Full Name
Chromobox 1
Introduction
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Entrez Gene ID
10951
UniProt ID
P83916
Alternative Names
Chromobox 1; Heterochromatin Protein 1 Homolog Beta; Modifier 1 Protein; HP1Hsbeta; P25beta; CBX; M31; Chromobox Homolog 1 (HP1 Beta Homolog Drosophila ); Chromobox Homolog 1 (Drosophila HP1 Beta); Heterochromatin Protein P25 Beta; HP1 Beta Homolog (Drosophila )
Function
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
Biological Process
Cellular response to DNA damage stimulus Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: Ensembl
Viral life cycle Source: Reactome
Cellular Location
Nucleus. Unassociated with chromosomes during mitosis.
PTM
Not phosphorylated.
Ubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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