Sign in or Register   Sign in or Register
  |  

Mouse Anti-CBX3 Antibody (2E1) (CBMAB-0202-YC)

Provided herein are mouse monoclonal antibodies against Human CBX3. The antibody clone 2E1 can be used for immunoassay techniques, such as IP and MA.
See all CBX3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E1
Antibody Isotype
IgG1
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chromobox 3
Introduction
CBX3 (chromobox 3) is a protein that is encoded by the CBX3 gene in human. CBX3 has been shown to interact with PIM1, Ki-67, Lamin B receptor, CBX5 and CBX1.
Entrez Gene ID
11335
UniProt ID
Q13185
Alternative Names
Chromobox Homolog 3; Heterochromatin Protein 1 Homolog Gamma; Modifier 2 Protein; HECH; Chromobox Homolog 3 (HP1 Gamma Homolog, Drosophila); Chromobox Homolog 3 (Drosophila HP1 Gamma); Heterochromatin Protein HP1 Gamma; HP1 Gamma Homolog (Drosophila); Heterochromatin-Like Protein 1; HP1 Gamma Homolog; HP1Hs-Gamma; HP1-GAMMA; HP1 Gamma
Function
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).
Biological Process
Cellular response to dexamethasone stimulus Source: Ensembl
Cellular response to DNA damage stimulus Source: UniProtKB
Chromatin remodeling Source: UniProtKB
Negative regulation of G0 to G1 transition Source: Reactome
Negative regulation of transcription, DNA-templated Source: UniProtKB
Rhythmic process Source: UniProtKB-KW
Cellular Location
Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).
PTM
Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.

Huang, Y., Lin, Y., Song, X., & Wu, D. (2021). LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma. Carcinogenesis, 42(5), 733-741.

Niu, H., Chen, P., Fan, L., & Sun, B. (2021). Comprehensive Pan-Cancer Analysis on CBX3 as a Prognostic and Immunological Biomarker.

He, Z., Chen, J., Chen, X., Wang, H., Tang, L., & Han, C. (2021). microRNA‐377 acts as a suppressor in esophageal squamous cell carcinoma through CBX3‐dependent P53/P21 pathway. Journal of cellular physiology, 236(1), 107-120.

Lin, H., Lian, J., Xia, L., Guan, G., & You, J. (2020). CBX3 promotes gastric cancer progression and affects factors related to immunotherapeutic responses. Cancer management and research, 12, 10113.

Bagheri, L., Thaler, R., Badreldin, A., Paradise, C. R., Khani, F., Deyle, D., ... & van Wijnen, A. (2020). Epigenetic Control of Osteoblast Differentiation by Chromobox 3 (Cbx3) Protein 3. The FASEB Journal, 34(S1), 1-1.

Lin, H., Zhao, X., Xia, L., Lian, J., & You, J. (2020). Clinicopathological and Prognostic Significance of CBX3 Expression in Human Cancer: a Systematic Review and Meta-analysis. Disease markers, 2020.

Liu, J., Zhan, Y., Wang, J., Wang, J., Guo, J., & Kong, D. (2020). lncRNA-SNHG17 promotes colon adenocarcinoma progression and serves as a sponge for miR-375 to regulate CBX3 expression. American Journal of Translational Research, 12(9), 5283.

Ma, C., Nie, X. G., Wang, Y. L., Liu, X. H., Liang, X., Zhou, Q. L., & Wu, D. P. (2019). CBX3 predicts an unfavorable prognosis and promotes tumorigenesis in osteosarcoma. Molecular medicine reports, 19(5), 4205-4212.

Zhang, H., Chen, W., Fu, X., Su, X., & Yang, A. (2018). CBX3 promotes tumor proliferation by regulating G1/S phase via p21 downregulation and associates with poor prognosis in tongue squamous cell carcinoma. Gene, 654, 49-56.

Meng, L., Wang, F., Sun, S., Zheng, Y., Ding, Z., Sun, Y., ... & Xu, M. (2017). MicroRNA-30b targets CBX3 and regulates cell proliferation, apoptosis, and migration in esophageal squamous cell carcinoma via the JAK2/STAT3 signaling pathway. International journal of clinical and experimental pathology, 10(12), 11828.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CBX3 Antibody (2E1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare