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CBX3

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Full Name
Chromobox 3
Alternative Names
Chromobox 3
Function
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).
Biological Process
Cellular response to dexamethasone stimulus Source: Ensembl
Cellular response to DNA damage stimulus Source: UniProtKB
Chromatin remodeling Source: UniProtKB
Negative regulation of G0 to G1 transition Source: Reactome
Negative regulation of transcription, DNA-templated Source: UniProtKB
Rhythmic process Source: UniProtKB-KW
Cellular Location
Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).
PTM
Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
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Anti-CBX3 antibodies

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Mouse Anti-CBX3 Recombinant Antibody (CBT51) (V2LY-0625-LY3838)

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Target: CBX3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT51
Application*: IF, IC, WB, P
Datasheet SDS

Mouse Anti-CBX3 Recombinant Antibody (CBT730) (V2LY-0625-LY3323)

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Target: CBX3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT730
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-CBX3 Recombinant Antibody (CBT731) (V2LY-0625-LY3322)

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Target: CBX3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT731
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-CBX3 Recombinant Antibody (CBT3654) (V2LY-0625-LY284)

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Target: CBX3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3654
Application*: IH, F
Datasheet SDS

Mouse Anti-CBX3 Recombinant Antibody (EC99) (V2LY-0624-LY99)

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Target: CBX3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC99
Application*: WB, P
Datasheet SDS

Mouse Anti-CBX3 Recombinant Antibody (EC98) (V2LY-0624-LY98)

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Target: CBX3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC98
Application*: WB, P
Datasheet SDS

Rat Anti-CBX3 Recombinant Antibody (MAC385) (CBMAB-C9782-LY)

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Target: CBX3
Host: Rat
Antibody Isotype: IgM
Specificity: Human, Mouse
Clone: MAC385
Application*: IF, E
Datasheet SDS

Mouse Anti-CBX3 Recombinant Antibody (1G12-1D9) (CBMAB-C4144-LY)

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Target: CBX3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G12-1D9
Application*: E, IF, WB
Datasheet SDS

Rabbit Anti-CBX3 Recombinant Antibody (CBFYH-0043) (CBMAB-H0860-FY)

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Target: CBX3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYH-0043
Application*: WB, P
Datasheet SDS

Rabbit Anti-CBX3 Monoclonal Antibody (CBFYH-2922) (CBMAB-H0859-FY)

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Target: CBX3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYH-2922
Application*: WB, P, E
Datasheet SDS

Mouse Anti-CBX3 Monoclonal Antibody (CBFYH-2921) (CBMAB-H0858-FY)

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Target: CBX3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-2921
Application*: E, WB
Datasheet SDS

Mouse Anti-CBX3 Monoclonal Antibody (CBFYH-2920) (CBMAB-H0857-FY)

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Target: CBX3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-2920
Application*: E, IF, IP, WB, P
Datasheet SDS

Mouse Anti-CBX3 Recombinant Antibody (CBFYH-0050) (CBMAB-H0555-FY)

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Target: CBX3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-0050
Application*: E, IF, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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