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CBX3

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]

Full Name

Chromobox 3

Function

Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).

Biological Process

Cellular response to dexamethasone stimulus Source: Ensembl
Cellular response to DNA damage stimulus Source: UniProtKB
Chromatin remodeling Source: UniProtKB
Negative regulation of G0 to G1 transition Source: Reactome
Negative regulation of transcription, DNA-templated Source: UniProtKB
Rhythmic process Source: UniProtKB-KW

Cellular Location

Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).

PTM

Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.

Anti-CBX3 antibodies

Mouse Anti-CBX3 Recombinant Antibody (CBXC-2953) (CBMAB-C5345-CQ)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Human, Monkey, Hamster, Rat

Clone: CBXC-2953

Application*: WB, IF

Mouse Anti-CBX3 Recombinant Antibody (CBXC-0100) (CBMAB-C5344-CQ)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXC-0100

Application*: E, WB

Mouse Anti-CBX3 Recombinant Antibody (CBXC-0099) (CBMAB-C5343-CQ)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXC-0099

Application*: E, IF, WB

Mouse Anti-CBX3 Recombinant Antibody (CBXC-0101) (CBMAB-C3204-CQ)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0101

Application*: IH, IP, WB

Mouse Anti-CBX3 Recombinant Antibody (CBYY-C1039) (CBMAB-C2476-YY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C1039

Application*: E, WB, P, F

Mouse Anti-CBX3 Recombinant Antibody (CBYY-C1038) (CBMAB-C2475-YY)

SDS

Target: CBX3

Host: Mouse

Specificity: Human, Monkey, Mouse, Rat

Clone: CBYY-C1038

Application*: IC, IH, IP, WB

Mouse Anti-CBX3 (AA 1-184) Recombinant Antibody (CBFYC-0900) (CBMAB-C0955-FY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYC-0900

Application*: IF, WB

Mouse Anti-CBX3 Recombinant Antibody (CBFYC-0899) (CBMAB-C0954-FY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYC-0899

Application*: WB, E, IF

Mouse Anti-CBX3 Recombinant Antibody (CBFYC-0898) (CBMAB-C0953-FY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBFYC-0898

Application*: E, IF, WB

Rat Anti-CBX3 Recombinant Antibody (CBFYM-0898) (CBMAB-M1046-FY)

SDS

Target: CBX3

Host: Rat

Antibody Isotype: IgM

Specificity: Human

Clone: CBFYM-0898

Application*: C, E

Mouse Anti-CBX3 Recombinant Antibody (CBFYH-0055) (CBMAB-H0871-FY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYH-0055

Application*: WB, P, C, F, IF

Mouse Anti-CBX3 Recombinant Antibody (CBFYH-0054) (CBMAB-H0870-FY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Monkey, Rat, Hamster

Clone: CBFYH-0054

Application*: ID, IF, IH, P, IP, WB

Mouse Anti-CBX3 Recombinant Antibody (CBFYH-0051) (CBMAB-H0867-FY)

SDS

Target: CBX3

Host: Mouse

Specificity: Human

Clone: CBFYH-0051

Application*: WB, IC, P, C, E

Mouse Anti-CBX3 (AA 114-173) Recombinant Antibody (CBFYH-0049) (CBMAB-H0866-FY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-0049

Application*: IP

Mouse Anti-CBX3 Recombinant Antibody (CBFYH-0048) (CBMAB-H0865-FY)

SDS

Target: CBX3

Host: Mouse

Specificity: Human, Mouse

Clone: CBFYH-0048

Application*: WB, IC, IP, IH

Mouse Anti-CBX3 Recombinant Antibody (CBFYH-0047) (CBMAB-H0864-FY)

SDS

Target: CBX3

Host: Mouse

Specificity: Human, Mouse, Rat

Clone: CBFYH-0047

Application*: WB, IH

Mouse Anti-CBX3 Recombinant Antibody (CBFYH-0046) (CBMAB-H0863-FY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBFYH-0046

Application*: WB, P

Mouse Anti-CBX3 (AA 17-173) Recombinant Antibody (CBFYH-0045) (CBMAB-H0862-FY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBFYH-0045

Application*: IH, IP, WB

Mouse Anti-CBX3 Recombinant Antibody (CBFYH-0044) (CBMAB-H0861-FY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBFYH-0044

Application*: E, IF, IH, WB

Mouse Anti-CBX3 Recombinant Antibody (CBFYH-0043) (CBMAB-H0860-FY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBFYH-0043

Application*: E, WB, IH, IF

Rat Anti-CBX3 Monoclonal Antibody (CBFYH-2922) (CBMAB-H0859-FY)

SDS

Target: CBX3

Host: Rat

Antibody Isotype: IgM

Specificity: Human, Mouse

Clone: CBFYH-2922

Application*: E, C

Mouse Anti-CBX3 Monoclonal Antibody (CBFYH-2921) (CBMAB-H0858-FY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Human, Monkey, Hamster, Rat

Clone: CBFYH-2921

Application*: WB, IF, IP, IH, IC

Mouse Anti-CBX3 Monoclonal Antibody (CBFYH-2920) (CBMAB-H0857-FY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBFYH-2920

Application*: CI, E, IC, IF, WB

Mouse Anti-CBX3 (AA 29-86) Recombinant Antibody (CBFYH-0050) (CBMAB-H0555-FY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBFYH-0050

Application*: F, IC, IF, IP, WB

Mouse Anti-CBX3 Recombinant Antibody (CBMAB-Z0248-LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat

Application*: WB, IH

Mouse Anti-CBX3 Recombinant Antibody (EG500) (CBMAB-EN568-LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: EG500

Application*: ELISA, WB

Mouse Anti-CBX3 Recombinant Antibody (CAP344) (CBMAB-AP847LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Monkey, Mouse, Rat

Clone: CAP344

Application*: ICC, IHC, IP, WB

Mouse Anti-CBX3 Recombinant Antibody (CAP343) (CBMAB-AP845LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CAP343

Application*: ELISA, IHC, WB

Mouse Anti-CBX3 Recombinant Antibody (CAP342) (CBMAB-AP844LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CAP342

Application*: ELISA, IHC, WB

Mouse Anti-CBX3 Recombinant Antibody (CAP341) (CBMAB-AP843LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CAP341

Application*: ELISA, IHC, WB

Mouse Anti-CBX3 Recombinant Antibody (CB334A) (CBMAB-CA334LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CB334A

Application*: ELISA, WB, IHC

Mouse Anti-CBX3 Recombinant Antibody (CB333A) (CBMAB-CA333LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CB333A

Application*: ELISA, WB, IHC

Mouse Anti-CBX3 Recombinant Antibody (CB332A) (CBMAB-CA332LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CB332A

Application*: ELISA, WB, IHC

Rat Anti-CBX3 Recombinant Antibody (MAC385) (CBMAB-C9782-LY)

SDS

Target: CBX3

Host: Rat

Antibody Isotype: IgM

Specificity: Human, Mouse

Clone: MAC385

Application*: C, E, WB

Mouse Anti-CBX3 Recombinant Antibody (S3) (CBMAB-C9783-LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: S3

Application*: E, WB

Mouse Anti-CBX3 Recombinant Antibody (6D1C4) (CBMAB-C8159-LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6D1C4

Application*: E, WB, P, F

Mouse Anti-CBX3 Recombinant Antibody (5G10) (CBMAB-C7653-LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Monkey, Mouse, Rat

Clone: 5G10

Application*: IC, IH, IP, WB

Rat Anti-CBX3 Recombinant Antibody (3H2612) (CBMAB-C6293-LY)

SDS

Target: CBX3

Host: Rat

Antibody Isotype: IgM

Specificity: Mouse

Clone: 3H2612

Application*: E, C, WB

Mouse Anti-CBX3 Recombinant Antibody (2Q2290) (CBMAB-C5351-LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 2Q2290

Application*: E, IF, C, WB

Mouse Anti-CBX3 Recombinant Antibody (2MOD-1G6) (CBMAB-C5322-LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Pig

Clone: 2MOD-1G6

Application*: P

Mouse Anti-CBX3 Recombinant Antibody (1G12-1D9) (CBMAB-C4144-LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1G12-1D9

Application*: E, IF, WB

Mouse Anti-CBX3 Recombinant Antibody (1A5A3) (CBMAB-C3558-LY)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: 1A5A3

Application*: E, IF, WB

Mouse Anti-CBX3 Antibody (2E1) (CBMAB-0202-YC)

SDS

Target: CBX3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2E1

Application*: IP, M

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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