Mouse Anti-CCL16 Recombinant Antibody (CBYY-C1062) (CBMAB-C2499-YY)

This product is mouse antibody that recognizes CCL16. The antibody CBYY-C1062 can be used for immunoassay techniques such as: IHC, Neut, WB
See all CCL16 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-C1062

Antibody Isotype

IgG1

Application

IHC, Neut, WB

Basic Information

Immunogen

Human recombinant CCL-16

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Protein G purified

Preservative

PBS

Concentration

Lyophilized

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

C-C Motif Chemokine Ligand 16

Entrez Gene ID

6360

UniProt ID

O15467

Function

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

Biological Process

Cell-cell signaling Source: ProtInc
Cell communication Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central

Cellular Location

Secreted

References

Romano-Munive, A. F., Moctezuma-Velázquez, C., Keil-Ríos, D., Sixtos-Alonso, S., Que-Rodríguez, R. I., & Kershenobich-Stalnikowitz, D. (2021). Plasma CCL16 Chemokine Secretion and Expression in Liver Tissue of Patients with Autoimmune Hepatitis: A Pilot Study. Acta Gastroenterológica Latinoamericana, 51(3), 321-326.

Zhuo, J. Y., Lu, D., Lin, Z. Y., Cen, B. N., Wei, X. Y., Xie, H. Y., ... & Xu, X. (2020). CC motif chemokine ligand 16 inhibits the progression of liver cirrhosis via inactivating hepatic stellate cells. Hepatobiliary & Pancreatic Diseases International, 19(5), 440-448.

Neves, F., Abrantes, J., Lopes, A. M., Fusinatto, L. A., Magalhães, M. J., van der Loo, W., & Esteves, P. J. (2019). Evolution of CCL16 in Glires (Rodentia and Lagomorpha) shows an unusual random pseudogenization pattern. BMC evolutionary biology, 19(1), 1-10.

Hayatbakhsh, M. M., Shabgah, A. G., Pishgouyi, S., Afshari, J. T., Zeidabadi, H., & Mohammadi, M. (2019). The Serum Levels of CCL2 and CCL16 Expression in Patients with Irritable Bowel Syndrome. Reports of biochemistry & molecular biology, 8(1), 9.

Wu, C. H., & Lin, K. H. (2018). The biological significance of CCL 16 regulated by thyroid hormone in liver cancer cells.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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