Mouse Anti-CCL16 Recombinant Antibody (CBYJL-1008) (CBMAB-L0415-YJ)

Name: Mouse Anti-CCL16 Recombinant Antibody (CBYJL-1008)
SKU: CBMAB-L0415-YJ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYJL-1008

Antibody Isotype

IgG1

Application

ELISA

Basic Information

Immunogen

Recombinant human CCL16/HCC-4/NCC4 Protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

C-C Motif Chemokine Ligand 16

Introduction

Cytokines are a family of secreted proteins function in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. C-C motif chemokine ligand 16 also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10.

Entrez Gene ID

6360

UniProt ID

O15467

Alternative Names

LEC; LMC; NCC4; CKb12; HCC-4; LCC-1; Mtn-1; NCC-4; SCYL4; ILINCK; SCYA16

Function

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

Biological Process

Cell-cell signaling Source: ProtInc
Cell communication Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central

Cellular Location

Secreted

More Infomation

References

Romano-Munive, A. F., Moctezuma-Velázquez, C., Keil-Ríos, D., Sixtos-Alonso, S., Que-Rodríguez, R. I., & Kershenobich-Stalnikowitz, D. (2021). Plasma CCL16 Chemokine Secretion and Expression in Liver Tissue of Patients with Autoimmune Hepatitis: A Pilot Study. Acta Gastroenterológica Latinoamericana, 51(3), 321-326.

Zhuo, J. Y., Lu, D., Lin, Z. Y., Cen, B. N., Wei, X. Y., Xie, H. Y., ... & Xu, X. (2020). CC motif chemokine ligand 16 inhibits the progression of liver cirrhosis via inactivating hepatic stellate cells. Hepatobiliary & Pancreatic Diseases International, 19(5), 440-448.

Neves, F., Abrantes, J., Lopes, A. M., Fusinatto, L. A., Magalhães, M. J., van der Loo, W., & Esteves, P. J. (2019). Evolution of CCL16 in Glires (Rodentia and Lagomorpha) shows an unusual random pseudogenization pattern. BMC evolutionary biology, 19(1), 1-10.

Hayatbakhsh, M. M., Shabgah, A. G., Pishgouyi, S., Afshari, J. T., Zeidabadi, H., & Mohammadi, M. (2019). The Serum Levels of CCL2 and CCL16 Expression in Patients with Irritable Bowel Syndrome. Reports of biochemistry & molecular biology, 8(1), 9.

Wu, C. H., & Lin, K. H. (2018). The biological significance of CCL 16 regulated by thyroid hormone in liver cancer cells.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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