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Recombinant Mouse Anti-CCNL1 Recombinant Antibody (2F10) (CBMAB-XB0138-YC)

Provided herein is a Mouse Recombinant Antibody against Cyclin L1. The antibody can be used for immunoassay techniques, such as ELISA, IHC, IF, WB.
See all CCNL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
2F10
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, IF, WB

Basic Information

Immunogen
(C)SKHHGGSRSGHGRHRR (Synthetic peptide corresponding to aa 511 to 526 of human Cyclin L1)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
cyclin L1
Introduction
CCNL1 (Cyclin L1) is a protein coding gene. Diseases associated with CCNL1 include Squamous Cell Carcinoma, Head And Neck. Gene Ontology annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNL2.
Entrez Gene ID
Human57018
Mouse56706
Rat114121
UniProt ID
HumanQ9UK58
MouseQ52KE7
RatQ9R1Q2
Alternative Names
Cyclin L1; Cyclin-L; Cyclin L Ania-6a; Cyclin L Gamma; Cyclin-L1; PRO1073; Ania-6a; ANIA6A; BM-001;
Function
Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018).
Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906).
May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).
Biological Process
Regulation of transcription by RNA polymerase II Source: GO_Central
RNA processing Source: InterPro
Cellular Location
Nucleus speckle; Nucleoplasm. Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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