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Mouse Anti-CCR4 Recombinant Antibody (CBXC-1006) (CBMAB-C1268-CQ)

This product is a mouse antibody that recognizes CCR4. The antibody CBXC-1006 can be used for immunoassay techniques such as: FC.
See all CCR4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBXC-1006
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
Human CCR4 transfectants, Met1-Leu360, Accession # P51679
Specificity
Human, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution containing BSA
Preservative
Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-C Motif Chemokine Receptor 4
Introduction
CCR4 (C-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CCR4 include Cutaneous T Cell Lymphoma and Mycosis Fungoides. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR5.
Entrez Gene ID
Human1233
Rat171054
UniProt ID
HumanP51679
RatG3V7C3
Alternative Names
C-C Motif Chemokine Receptor 4; Chemokine (C-C Motif) Receptor 4; C-C CKR-4; CC-CKR-4; CMKBR4; CCR-4; K5-5; C-C Chemokine Receptor Type 4;
Function
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Biological Process
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Homeostasis of number of cells Source: Ensembl
Immune response Source: GO_Central
Inflammatory response Source: ProtInc
Neuron migration Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of positive chemotaxis Source: Ensembl
Response to antibiotic Source: Ensembl
Response to bacterium Source: Ensembl
Response to radiation Source: Ensembl
Tolerance induction Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-39
Helical: 40-67
Cytoplasmic: 68-77
Helical: 78-98
Extracellular: 99-111
Helical: 112-133
Cytoplasmic: 134-150
Helical: 151-175
Extracellular: 176-206
Helical: 207-226
Cytoplasmic: 227-242
Helical: 243-267
Extracellular: 268-284
Helical: 285-308
Cytoplasmic: 309-360
PTM
In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.

Xu, H., Lin, S., & Huang, H. (2021). Involvement of increased expression of chemokine C–C motif chemokine 22 (CCL22)/CC chemokine receptor 4 (CCR4) in the inflammatory injury and cartilage degradation of chondrocytes. Cytotechnology, 73(5), 715-726.

Lim, H. D., Lane, J. R., Canals, M., & Stone, M. J. (2021). Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10. International Journal of Molecular Sciences, 22(8), 4232.

Tang, N., Zhang, Y. Y., Cheng, J. H., Zhao, Z. B., & Fan, Y. (2021). Cross-talk between CXC chemokine ligand 10-CXC chemokine receptor 3 axis and CC chemokine ligand 17-CC chemokine receptor 4 axis in the pathogenesis of oral lichen planus. Hua xi kou Qiang yi xue za zhi= Huaxi Kouqiang Yixue Zazhi= West China Journal of Stomatology, 39(4), 405-412.

Dong, Y., Gao, S., Zhang, X., Kou, J., Liu, J., Ye, T., & Shen, H. (2021). CCL17 and CCL22 induce CCR4 receptor expression and promote cytokine-induced killer cells migration. Anti-cancer Drugs.

Dabbaghmanesh, M. H., Rezaei, B., Haghshenas, M. R., Montazeri-Najafabady, N., Mohammadian Amiri, R., & Erfani, N. (2021). CCR4 1014C/T and CCL22 16C/A Genetic Variations in the Iranian Patients with Thyroid Cancer. Middle East Journal of Cancer.

Ohuchi, K., Fujimura, T., Lyu, C., Amagai, R., Muto, Y., & Aiba, S. (2020). Serum CCL22 levels decreased in parallel with disease activity in CCR4‐positive mycosis fungoides treated with mogamulizumab. Dermatologic Therapy, 33(6), e14099.

Zhong, Y., Lin, Z., Lu, J., Lin, X., Xu, W., Wang, N., ... & Lin, S. (2019). CCL2-CCL5/CCR4 contributed to radiation-induced epithelial-mesenchymal transition of HPAEpiC cells via the ERK signaling pathways. American journal of translational research, 11(2), 733.

Wang, L., Zhang, M., Zhu, Y., Zhang, X., Yang, Y., & Wang, C. (2019). CCR4 expression is associated with poor prognosis in patients with early stage (pN0) oral tongue cancer. Journal of Oral and Maxillofacial Surgery, 77(2), 426-432.

Sato, T., & Yamano, Y. (2018). Targeting human T‐lymphotropic virus type 1‐infected cells with an anti‐C‐C chemokine receptor 4 antibody in T‐lymphotropic virus type 1‐associated myelopathy. Clinical and Experimental Neuroimmunology, 9(3), 153-154.

Klein, A., Sagi-Assif, O., Meshel, T., Telerman, A., Izraely, S., Ben-Menachem, S., ... & Witz, I. P. (2017). CCR4 is a determinant of melanoma brain metastasis. Oncotarget, 8(19), 31079.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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