CCR4

CCR4 (C-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CCR4 include Cutaneous T Cell Lymphoma and Mycosis Fungoides. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR5.
Full Name
C-C Motif Chemokine Receptor 4
Function
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Biological Process
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Homeostasis of number of cells Source: Ensembl
Immune response Source: GO_Central
Inflammatory response Source: ProtInc
Neuron migration Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of positive chemotaxis Source: Ensembl
Response to antibiotic Source: Ensembl
Response to bacterium Source: Ensembl
Response to radiation Source: Ensembl
Tolerance induction Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-39
Helical: 40-67
Cytoplasmic: 68-77
Helical: 78-98
Extracellular: 99-111
Helical: 112-133
Cytoplasmic: 134-150
Helical: 151-175
Extracellular: 176-206
Helical: 207-226
Cytoplasmic: 227-242
Helical: 243-267
Extracellular: 268-284
Helical: 285-308
Cytoplasmic: 309-360
PTM
In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
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Anti-CCR4 antibodies

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Mouse Anti-CCR4 Recombinant Antibody (205410) (CBMAB-C0585-LY)

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Target: CCR4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 205410
Application*: F
Datasheet SDS

Human Anti-CCR4 Recombinant Antibody (
12F5) (V2LY-0725-LY619)

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Target: CCR4
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 12F5
Application*: E, F
Datasheet SDS

Rabbit Anti-CCR4 Recombinant Antibody (EG520) (CBMAB-EN593-LY)

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Target: CCR4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG520
Application*: WB, IF
Datasheet SDS

Human Anti-CCR4 Recombinant Antibody (CBXC-0785) (CBMAB-C1899-CQ)

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Target: CCR4
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0785
Application*: F
Datasheet SDS

Rabbit Anti-CCR4 Recombinant Antibody (CBFYC-1075) (CBMAB-C1132-FY)

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Target: CCR4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-1075
Application*: F
Datasheet SDS

Mouse Anti-CCR4 Recombinant Antibody (CBFYC-0428) (CBMAB-C0474-FY)

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Target: CCR4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0428
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CCR4 Recombinant Antibody (CBFYC-0403) (CBMAB-C0444-FY)

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Target: CCR4
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0403
Application*: WB, IP, IF, E, F
Datasheet SDS

Mouse Anti-CCR4 Recombinant Antibody (9G12) (CBMAB-C9327-LY)

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Target: CCR4
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 9G12
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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