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Mouse Anti-CCRL2 Recombinant Antibody (14L140) (CBMAB-C1507-CN)

This product is a Mouse antibody that recognizes CCRL2. The antibody 14L140 can be used for immunoassay techniques such as: FC.
See all CCRL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
14L140
Antibody Isotype
IgG2
Application
FC

Basic Information

Immunogen
Recombinant protein corresponding to human CCRL-2
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS. Reconstitute with 0.2 mL sterile PBS
Concentration
0.5 mg/mL (after reconstitution)

Target

Full Name
C-C Motif Chemokine Receptor Like 2
Introduction
CCRL2 (C-C Motif Chemokine Receptor Like 2) is a Protein Coding gene. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor binding.
Entrez Gene ID
9034
UniProt ID
O00421
Alternative Names
C-C Motif Chemokine Receptor Like 2; Chemokine (C-C Motif) Receptor-Like 2; Putative MCP-1 Chemokine Receptor; Atypical Chemokine Receptor 5; Chemokine Receptor CCR11; Chemokine Receptor X; CKRX; CRAM;
Function
Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
Biological Process
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: ProtInc
Immune response Source: GO_Central
Inflammatory response Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-43
Helical: 44-64
Cytoplasmic: 65-74
Helical: 75-95
Extracellular: 96-104
Helical: 105-125
Cytoplasmic: 126-144
Helical: 145-165
Extracellular: 166-198
Helical: 199-219
Cytoplasmic: 220-238
Helical: 239-259
Extracellular: 260-286
Helical: 287-307
Cytoplasmic: 308-344

Islam, S., Moni, M. A., Urmi, U. L., Tanaka, A., & Hoshino, H. (2021). CC Chemokine receptor-like 2 (CCRL2) acts as coreceptor for human immunodeficiency virus-2. Briefings in Bioinformatics, 22(4), bbaa333.

Yin, W., Li, Y., Song, Y., Zhang, J., Wu, C., Chen, Y., ... & He, R. (2021). CCRL2 promotes antitumor T-cell immunity via amplifying TLR4-mediated immunostimulatory macrophage activation. Proceedings of the National Academy of Sciences, 118(16).

Schioppa, T., Sozio, F., Barbazza, I., Scutera, S., Bosisio, D., Sozzani, S., & Del Prete, A. (2020). Molecular basis for CCRL2 regulation of leukocyte migration. Frontiers in Cell and Developmental Biology, 8, 1570.

Zhang, Y., Li, S., Liu, Q., Long, R., Feng, J., Qin, H., ... & Luo, J. (2020). Mycobacterium tuberculosis heat-shock protein 16.3 induces macrophage M2 polarization through CCRL2/CX3CR1. Inflammation, 43(2), 487-506.

Xu, M., Wang, Y. M., Li, W. Q., Huang, C. L., Li, J., Xie, W. H., ... & Li, X. (2020). Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration. Genes & Diseases.

Reyes, N., Benedetti, I., Rebollo, J., Correa, O., & Geliebter, J. (2019). Atypical chemokine receptor CCRL2 is overexpressed in prostate cancer cells. Journal of biomedical research, 33(1), 17.

Del Prete, A., Sozio, F., Schioppa, T., Ponzetta, A., Vermi, W., Calza, S., ... & Sozzani, S. (2019). The atypical receptor CCRL2 is essential for NK cell-dependent resistance against lung cancer. Cancer immunology research, 7(11), 1775.

Mazzotti, C., Gagliostro, V., Bosisio, D., Del Prete, A., Tiberio, L., Thelen, M., & Sozzani, S. (2017). The atypical receptor CCRL2 (CC Chemokine Receptor-Like 2) does not act as a decoy receptor in endothelial cells. Frontiers in immunology, 8, 1233.

Zimny, S., Pohl, R., Rein-Fischboeck, L., Haberl, E. M., Krautbauer, S., Weiss, T. S., & Buechler, C. (2017). Chemokine (CC-motif) receptor-like 2 mRNA is expressed in hepatic stellate cells and is positively associated with characteristics of non-alcoholic steatohepatitis in mice and men. Experimental and molecular pathology, 103(1), 1-8.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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