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Rabbit Anti-CD8B Recombinant Antibody (CBFYC-1489) (CBMAB-C1547-FY)

This product is rabbit antibody that recognizes CD8B. The antibody CBFYC-1489 can be used for immunoassay techniques such as: ELISA.
See all CD8B antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYC-1489
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human CD8BP37LEU2 Protein
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD8b Molecule
Introduction
CD8B (CD8b Molecule) is a Protein Coding gene. Diseases associated with CD8B include Mucinous Stomach Adenocarcinoma. Among its related pathways are T-Cell Receptor and Co-stimulatory Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include coreceptor activity and MHC class I protein binding.
Entrez Gene ID
926
UniProt ID
P10966
Alternative Names
CD8b Molecule; CD8 Antigen, Beta Polypeptide 1 (P37); CD8B1; T Lymphocyte Surface Glycoprotein Beta Chain; T-Cell Surface Glycoprotein CD8 Beta Chain; CD8b Antigen
Function
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Immune response Source: UniProtKB
Regulation of defense response to virus by virus Source: Reactome
Regulation of immune response Source: Reactome
T cell activation Source: UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Cellular Location
Isoform 1&2&4&5: Cell membrane. Requires the partner CD8A for efficient cell surface expression (PubMed:3145196). The heterodimer CD8A/CD8B localizes to lipid rafts due to CD8B cytoplasmic tail palmitoylation.
Isoform 3&6&7&8: Secreted
Topology
Extracellular: 22-170
Helical: 171-191
Cytoplasmic: 192-210
PTM
Phosphorylated as a consequence of T-cell activation.
Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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