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CD8B

CD8B (CD8b Molecule) is a Protein Coding gene. Diseases associated with CD8B include Mucinous Stomach Adenocarcinoma. Among its related pathways are T-Cell Receptor and Co-stimulatory Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include coreceptor activity and MHC class I protein binding.
Full Name
CD8b Molecule
Function
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Immune response Source: UniProtKB
Regulation of defense response to virus by virus Source: Reactome
Regulation of immune response Source: Reactome
T cell activation Source: UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Cellular Location
Isoform 1&2&4&5: Cell membrane. Requires the partner CD8A for efficient cell surface expression (PubMed:3145196). The heterodimer CD8A/CD8B localizes to lipid rafts due to CD8B cytoplasmic tail palmitoylation.
Isoform 3&6&7&8: Secreted
Topology
Extracellular: 22-170
Helical: 171-191
Cytoplasmic: 192-210
PTM
Phosphorylated as a consequence of T-cell activation.
Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers.
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Anti-CD8B antibodies

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Rat Anti-CD8B Recombinant Antibody (CBYY-C1647) (CBMAB-C3085-YY)

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Target: CD8B
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-C1647
Application*: IP, IF, P, F
Datasheet SDS

Rat Anti-CD8B Recombinant Antibody (53-5.8) (CBMAB-C7161-LY)

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Target: CD8B
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: 53-5.8
Application*: IF, in vivo
In Vivo Assay
Datasheet SDS

Mouse Anti-CD8B Recombinant Antibody (4C8) (CBMAB-C6748-LY)

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Target: CD8B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4C8
Application*: E
Datasheet SDS

Rabbit Anti-CD8B Recombinant Antibody (39) (CBMAB-C1735-LY)

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Target: CD8B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 39
Application*: P
Datasheet SDS

Rabbit Anti-CD8B Recombinant Antibody (25) (CBMAB-C1686-LY)

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Target: CD8B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 25
Application*: E
Datasheet SDS

Mouse Anti-CD8B Recombinant Antibody (CBFYC-1488) (CBMAB-C1546-FY)

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Target: CD8B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Sheep, Goat
Clone: CBFYC-1488
Application*: F
Datasheet SDS

Rat Anti-CD8B Recombinant Antibody (CBFYC-1487) (CBMAB-C1545-FY)

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Target: CD8B
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYC-1487
Application*: IH
Datasheet SDS

Mouse Anti-CD8B Recombinant Antibody (CBFYC-1486) (CBMAB-C1544-FY)

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Target: CD8B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-1486
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-CD8B Recombinant Antibody (CBFYC-0178) (CBMAB-C0201-FY)

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Target: CD8B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0178
Application*: WB, IP, IF, P, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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