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CD8B

CD8B (CD8b Molecule) is a Protein Coding gene. Diseases associated with CD8B include Mucinous Stomach Adenocarcinoma. Among its related pathways are T-Cell Receptor and Co-stimulatory Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include coreceptor activity and MHC class I protein binding.
Full Name
CD8b Molecule
Function
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Immune response Source: UniProtKB
Regulation of defense response to virus by virus Source: Reactome
Regulation of immune response Source: Reactome
T cell activation Source: UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Cellular Location
Isoform 1&2&4&5: Cell membrane. Requires the partner CD8A for efficient cell surface expression (PubMed:3145196). The heterodimer CD8A/CD8B localizes to lipid rafts due to CD8B cytoplasmic tail palmitoylation.
Isoform 3&6&7&8: Secreted
Topology
Extracellular: 22-170
Helical: 171-191
Cytoplasmic: 192-210
PTM
Phosphorylated as a consequence of T-cell activation.
Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers.

Anti-CD8B antibodies

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Mouse Anti-CD8B Recombinant Antibody (Du CD8-1) (CBMAB-C1999-CN)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Duck
Clone: Du CD8-1
Application*: IP, FC

Mouse Anti-CD8B Recombinant Antibody (10B2019) (CBMAB-C1995-CN)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cat
Clone: 10B2019
Application*: FC

Mouse Anti-CD8B Recombinant Antibody (10B2017) (CBMAB-C1994-CN)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: 10B2017
Application*: FC, IH, IP

Mouse Anti-CD8B Recombinant Antibody (V45P5C6/G8) (CBMAB-C0869-CN)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Fish
Clone: V45P5C6/G8
Application*: E

Mouse Anti-CD8B Recombinant Antibody (6A240) (CBMAB-C7994-LY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 6A240
Application*: F, IP

Rat Anti-CD8B Recombinant Antibody (53-5.8) (CBMAB-C7161-LY)

Datasheet SDS
Target: CD8B
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: 53-5.8
Application*: IP, IF, F

Mouse Anti-CD8B Recombinant Antibody (4C8) (CBMAB-C6748-LY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4C8
Application*: E

Mouse Anti-CD8B Recombinant Antibody (3H901) (CBMAB-C6372-LY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3H901
Application*: F, IP

Rabbit Anti-CD8B Recombinant Antibody (039) (CBMAB-C1735-LY)

Datasheet SDS
Target: CD8B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 039
Application*: P

Rabbit Anti-CD8B Recombinant Antibody (025) (CBMAB-C1686-LY)

Datasheet SDS
Target: CD8B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 025
Application*: E

Mouse Anti-CD8B Recombinant Antibody (341) (CBMAB-C0998-LY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: 341
Application*: F, C, IH

Mouse Anti-CD8B Recombinant Antibody (10B2015) (CBMAB-C0159-LY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Sheep
Clone: 10B2015
Application*: F, IP

Mouse Anti-CD8B Recombinant Antibody (CBXC-0279) (CBMAB-C4298-CQ)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-0279
Application*: F, IP

Mouse Anti-CD8B Recombinant Antibody (BU88) (CBMAB-C4297-CQ)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: BU88
Application*: F, IF

Human Anti-CD8B Recombinant Antibody (CBXC-0919) (CBMAB-C2034-CQ)

Datasheet SDS
Target: CD8B
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0919
Application*: F

Rabbit Anti-CD8B Recombinant Antibody (CBFYC-1490) (CBMAB-C1548-FY)

Datasheet SDS
Target: CD8B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-1490
Application*: P

Rabbit Anti-CD8B Recombinant Antibody (CBFYC-1489) (CBMAB-C1547-FY)

Datasheet SDS
Target: CD8B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-1489
Application*: E

Mouse Anti-CD8B Recombinant Antibody (CBFYC-1488) (CBMAB-C1546-FY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYC-1488
Application*: F

Mouse Anti-CD8B Recombinant Antibody (CBFYC-1487) (CBMAB-C1545-FY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: CBFYC-1487
Application*: F

Mouse Anti-CD8B Recombinant Antibody (CBFYC-1486) (CBMAB-C1544-FY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Chicken
Clone: CBFYC-1486
Application*: F, IH

Mouse Anti-CD8B Recombinant Antibody (CBFYC-0178) (CBMAB-C0201-FY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Goat, Sheep
Clone: CBFYC-0178
Application*: F, IP

Mouse Anti-CD8B Recombinant Antibody (G8) (CBMAB-AP1328LY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Fish
Clone: G8
Application*: Dot blot, ELISA

Rabbit Anti-CD8B Recombinant Antibody (D7C8H) (CBMAB-CP0235-LY)

Datasheet SDS
Target: CD8B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: D7C8H
Application*: WB

Mouse Anti-CD8B Recombinant Antibody (3H909) (CBMAB-C10735-LY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 3H909
Application*: F

Mouse Anti-CD8B Recombinant Antibody (TU-30) (CBMAB-C10738-LY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: TU-30
Application*: IH, F

Rat Anti-CD8B Recombinant Antibody (CT-CD8b) (CBMAB-C10729-LY)

Datasheet SDS
Target: CD8B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CT-CD8b
Application*: F

Rat Anti-CD8B Recombinant Antibody (H35-17.2) (CBMAB-C10730-LY)

Datasheet SDS
Target: CD8B
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: H35-17.2
Application*: F

Mouse Anti-CD8B Recombinant Antibody (SIDI8BEE) (CBMAB-C10732-LY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SIDI8BEE
Application*: F

Rat Anti-CD8B Recombinant Antibody (YTS156.7.7) (CBMAB-C10734-LY)

Datasheet SDS
Target: CD8B
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: YTS156.7.7
Application*: F

Mouse Anti-CD8B Recombinant Antibody (PPT23) (CBMAB-C10731-LY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: PPT23
Application*: F

Recombinant Mouse Anti-CD8b Recombinant Antibody (V45P5C6) (CBMAB-XB0211-YC)

Datasheet SDS
Target: CD8b
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Stickleback
Clone: V45P5C6
Application*: E

Mouse Anti-CD8B Recombinant Antibody (3.4.1) (CBMAB-C12685-LY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 3.4.1
Application*: F

Mouse Anti-CD8B Recombinant Antibody (CBYY-C1648) (CBMAB-C3086-YY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYY-C1648
Application*: F, IP

Mouse Anti-CD8B Recombinant Antibody (CBYY-C1647) (CBMAB-C3085-YY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C1647
Application*: E

Mouse Anti-CD8B Recombinant Antibody (CBYY-C0480) (CBMAB-C1438-YY)

Datasheet SDS
Target: CD8B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Chicken
Clone: CBYY-C0480
Application*: F, IH, IP
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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