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Mouse Anti-CDH6 Antibody (CCD6B-1) (CBMAB-1055CQ)

This product is a mouse antibody that recognizes CDH6. The antibody CCD6B-1 can be used for immunoassay techniques such as: IF, IHC, WB.
See all CDH6 antibodies

Summary

Host Animal
Mouse
Specificity
Chicken, Human
Clone
CCD6B-1
Antibody Isotype
IgG1, λ
Application
IF, IHC, WB

Basic Information

Immunogen
Recombinant chicken cadherin-7 (N-terminal 597 aa) fused to human Fc; expressed in COS-7 cells
Specificity
Chicken, Human
Antibody Isotype
IgG1, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Extracellular domain

Target

Full Name
Cadherin 6
Introduction
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Diseases associated with CDH6 include Renal Cell Carcinoma. Among its related pathways are Ectoderm Differentiation and TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition.
Entrez Gene ID
Human1004
Chicken414842
UniProt ID
HumanP55285
ChickenQ90762
Alternative Names
c-cad6B; cad6B
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Biological Process
Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Multicellular organism development Source: GO_Central
Notch signaling pathway Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 54-615
Helical: 616-636
Cytoplasmic: 637-790

Zhao, Z., Li, S., Li, S., Wang, J., Lin, H., & Fu, W. (2021). High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer. Cancer cell international, 21(1), 1-9.

Gugnoni, M., Manicardi, V., Torricelli, F., Sauta, E., Bellazzi, R., Manzotti, G., ... & Ciarrocchi, A. (2021). Linc00941 is a novel transforming growth factor β target that primes papillary thyroid cancer metastatic behavior by regulating the expression of cadherin 6. Thyroid, 31(2), 247-263.

Bouck, E. G., de la Fuente, M., Zunica, E. R., Li, W., Mumaw, M. M., & Nieman, M. T. (2021). Murine cadherin‐6 mediates thrombosis in vivo in a platelet‐independent manner. Research and Practice in Thrombosis and Haemostasis, 5(1), 125-131.

Zhao, Z., Li, S., Li, S., Wang, J., Lin, H., & Fu, W. (2021). Overexpression of a novel oncogene Cadherin 6 correlates with tumor progression and poor prognosis in gastric cancer.

Ma, C., Zhao, J. Z., Lin, R. T., Zhou, L., Chen, Y. N., Yu, L. J., ... & Zhang, T. (2018). Combined overexpression of cadherin 6, cadherin 11 and cluster of differentiation 44 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma. Oncology letters, 15(6), 9498-9506.

Gugnoni, M., Sancisi, V., Gandolfi, G., Manzotti, G., Ragazzi, M., Giordano, D., ... & Ciarrocchi, A. (2017). Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy. Oncogene, 36(5), 667-677.

Zuo, L. L., Zhang, J., Liu, L. Z., Zhou, Q., Du, S. J., Xin, S. Y., ... & Lu, J. H. (2017). Cadherin 6 is activated by Epstein–Barr virus LMP1 to mediate EMT and metastasis as an interplay node of multiple pathways in nasopharyngeal carcinoma. Oncogenesis, 6(12), 1-16.

Bialucha, C. U., Collins, S. D., Li, X., Saxena, P., Zhang, X., Dürr, C., ... & Lees, E. (2017). Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer discovery, 7(9), 1030-1045.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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