Mouse Anti-CDH6 Recombinant Antibody (CBFYC-1573) (CBMAB-C1632-FY)

Name: Mouse Anti-CDH6 Recombinant Antibody (CBFYC-1573)
SKU: CBMAB-C1632-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-1573

Application

ELISA

Immunogen

Recombinant Human Cadherin-6K-CadherinCDH6 protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Cadherin 6

Introduction

CDH6 (Cadherin 6) is a Protein Coding gene. Diseases associated with CDH6 include Renal Cell Carcinoma, Nonpapillary. Among its related pathways are Ectoderm Differentiation and ERK Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH10.

Entrez Gene ID

1004

UniProt ID

P55285

Alternative Names

Cadherin 6; Cadherin 6, Type 2, K-Cadherin (Fetal Kidney); K-Cadherin; Kidney Cadherin; Cadherin-6; CAD6; KCAD

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Biological Process

Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Multicellular organism development Source: GO_Central
Notch signaling pathway Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 54-615
Helical: 616-636
Cytoplasmic: 637-790

Zhao, Z., Li, S., Li, S., Wang, J., Lin, H., & Fu, W. (2021). High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer. Cancer cell international, 21(1), 1-9.

Gugnoni, M., Manicardi, V., Torricelli, F., Sauta, E., Bellazzi, R., Manzotti, G., ... & Ciarrocchi, A. (2021). Linc00941 is a novel transforming growth factor β target that primes papillary thyroid cancer metastatic behavior by regulating the expression of cadherin 6. Thyroid, 31(2), 247-263.

Bouck, E. G., de la Fuente, M., Zunica, E. R., Li, W., Mumaw, M. M., & Nieman, M. T. (2021). Murine cadherin‐6 mediates thrombosis in vivo in a platelet‐independent manner. Research and Practice in Thrombosis and Haemostasis, 5(1), 125-131.

Zhao, Z., Li, S., Li, S., Wang, J., Lin, H., & Fu, W. (2021). Overexpression of a novel oncogene Cadherin 6 correlates with tumor progression and poor prognosis in gastric cancer.

Ma, C., Zhao, J. Z., Lin, R. T., Zhou, L., Chen, Y. N., Yu, L. J., ... & Zhang, T. (2018). Combined overexpression of cadherin 6, cadherin 11 and cluster of differentiation 44 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma. Oncology letters, 15(6), 9498-9506.

Gugnoni, M., Sancisi, V., Gandolfi, G., Manzotti, G., Ragazzi, M., Giordano, D., ... & Ciarrocchi, A. (2017). Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy. Oncogene, 36(5), 667-677.

Zuo, L. L., Zhang, J., Liu, L. Z., Zhou, Q., Du, S. J., Xin, S. Y., ... & Lu, J. H. (2017). Cadherin 6 is activated by Epstein–Barr virus LMP1 to mediate EMT and metastasis as an interplay node of multiple pathways in nasopharyngeal carcinoma. Oncogenesis, 6(12), 1-16.

Bialucha, C. U., Collins, S. D., Li, X., Saxena, P., Zhang, X., Dürr, C., ... & Lees, E. (2017). Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer discovery, 7(9), 1030-1045.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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