Rat Recombinant CDH6 protein, His Tag (V2LY-0526-LY9192)

Name: Rat Recombinant CDH6 protein, His Tag
SKU: V2LY-0526-LY9192
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rat

Tag

His Tag

Protein Construction

This product is Rat Recombinant CDH6 protein, His Tag consist of Amino Acid: 1-615 and predicts a molecular mass of 67.9 kDa.

Molecule Mass

67.9 kDa

Sequence

Amino Acid: 1-615

Species

Rat

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>80% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tirs, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Cadherin 6

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Biological Process

Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Multicellular organism development Source: GO_Central
Notch signaling pathway Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 54-615
Helical: 616-636
Cytoplasmic: 637-790

Zhao, Z., Li, S., Li, S., Wang, J., Lin, H., & Fu, W. (2021). High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer. Cancer cell international, 21(1), 1-9.

Gugnoni, M., Manicardi, V., Torricelli, F., Sauta, E., Bellazzi, R., Manzotti, G., ... & Ciarrocchi, A. (2021). Linc00941 is a novel transforming growth factor β target that primes papillary thyroid cancer metastatic behavior by regulating the expression of cadherin 6. Thyroid, 31(2), 247-263.

Bouck, E. G., de la Fuente, M., Zunica, E. R., Li, W., Mumaw, M. M., & Nieman, M. T. (2021). Murine cadherin‐6 mediates thrombosis in vivo in a platelet‐independent manner. Research and Practice in Thrombosis and Haemostasis, 5(1), 125-131.

Zhao, Z., Li, S., Li, S., Wang, J., Lin, H., & Fu, W. (2021). Overexpression of a novel oncogene Cadherin 6 correlates with tumor progression and poor prognosis in gastric cancer.

Ma, C., Zhao, J. Z., Lin, R. T., Zhou, L., Chen, Y. N., Yu, L. J., ... & Zhang, T. (2018). Combined overexpression of cadherin 6, cadherin 11 and cluster of differentiation 44 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma. Oncology letters, 15(6), 9498-9506.

Gugnoni, M., Sancisi, V., Gandolfi, G., Manzotti, G., Ragazzi, M., Giordano, D., ... & Ciarrocchi, A. (2017). Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy. Oncogene, 36(5), 667-677.

Zuo, L. L., Zhang, J., Liu, L. Z., Zhou, Q., Du, S. J., Xin, S. Y., ... & Lu, J. H. (2017). Cadherin 6 is activated by Epstein–Barr virus LMP1 to mediate EMT and metastasis as an interplay node of multiple pathways in nasopharyngeal carcinoma. Oncogenesis, 6(12), 1-16.

Bialucha, C. U., Collins, S. D., Li, X., Saxena, P., Zhang, X., Dürr, C., ... & Lees, E. (2017). Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer discovery, 7(9), 1030-1045.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant CDH6 protein, ECD, His Tag (CAT#: V2LY-0526-LY1398)

Cynomolgus Recombinant CDH6 protein, His Tag (CAT#: V2LY-0526-LY1399)

Human Recombinant CDH6 protein, ECD, His Tag (CAT#: V2LY-0526-LY2498)

Human Recombinant CDH6 protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY2499)

Mouse Recombinant CDH6 protein, His Tag (CAT#: V2LY-0526-LY7896)

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Cynomolgus Recombinant CDH6 protein, ECD, His Tag (CAT#: V2LY-0526-LY1398)

Mouse Anti-CDH6 Recombinant Antibody (2B6) (CAT#: CBMAB-K0263-LY)

Mouse Recombinant CDH6 protein, His Tag (CAT#: V2LY-0526-LY7896)

Human Recombinant CDH6 protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY2499)

Human Recombinant CDH6 protein, ECD, His Tag (CAT#: V2LY-0526-LY2498)

Human Anti-CDH6 Recombinant Antibody (CBYY-C0220) (CAT#: CBMAB-C0634-YY)

Cynomolgus Recombinant CDH6 protein, His Tag (CAT#: V2LY-0526-LY1399)

Mouse Anti-CDH6 Recombinant Antibody (2F2) (CAT#: CBMAB-C5069-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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