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Rabbit Anti-CDK11B Recombinant Antibody (D88B3) (CBMAB-P0167-YC)

Provided herein is a Rabbit monoclonal antibody against Human Cyclin Dependent Kinase 11B. The antibody can be used for immunoassay techniques, such as WB, IP, IF.
See all CDK11B antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Monkey, Rat
Clone
D88B3
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Human, Mouse, Monkey, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cyclin Dependent Kinase 11B
Introduction
CDK11B (Cyclin Dependent Kinase 11B) is a protein coding gene. Diseases associated with CDK11B include Neuroblastoma. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and DNA Damage. Gene Ontology annotations related to this gene include protein kinase activity. An important paralog of the gene is CDK11A.
Entrez Gene ID
Human984
Mouse12537
Rat252879
Monkey703046
UniProt ID
HumanP21127
MouseP24788
RatP46892
Alternative Names
Cyclin Dependent Kinase 11B; Galactosyltransferase-Associated Protein Kinase P58/GTA; Cell Division Cycle 2-Like 1 (PITSLRE Proteins); PITSLRE Serine/Threonine-Protein Kinase CDC2L1; Cell Division Protein Kinase 11B; EC 2.7.11.22; P58 CLK-1; PITSLREA; CDC2L1; CDK11; CLK-1; PK58;
Function
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
Biological Process
Apoptotic process Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cell growth Source: UniProtKB
Regulation of mitotic cell cycle Source: GO_Central
Regulation of mRNA processing Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus
PTM
During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.
Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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