CDK11B

CDK11B (Cyclin Dependent Kinase 11B) is a Protein Coding gene. Diseases associated with CDK11B include Neuroblastoma. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and DNA Damage. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is CDK11A.

Full Name

Cyclin Dependent Kinase 11B

Function

Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.

Biological Process

Apoptotic process Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cell growth Source: UniProtKB
Regulation of mitotic cell cycle Source: GO_Central
Regulation of mRNA processing Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Cytoplasm; Nucleus

PTM

During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.
Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.

Anti-CDK11B antibodies

Rabbit Anti-CDK11B Recombinant Antibody (EG566) (CBMAB-EN685-LY)

Datasheet

SDS

Target: CDK11B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: EG566

Application*: WB: 1:500~1:1000 ELISA: 1:20000

Rabbit Anti-CDK11B Recombinant Antibody (D88B3) (CBMAB-P0167-YC)

Datasheet

SDS

Target: CDK11B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Monkey, Rat

Clone: D88B3

Application*: WB, IP, IF

Mouse Anti-CDK11B Recombinant Antibody (CBYY-C1754) (CBMAB-C3192-YY)

Datasheet

SDS

Target: CDK11B

Host: Mouse

Specificity: Human

Clone: CBYY-C1754

Application*: WB, IP, IF, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)