CDK11B

CDK11B (Cyclin Dependent Kinase 11B) is a Protein Coding gene. Diseases associated with CDK11B include Neuroblastoma. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and DNA Damage. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is CDK11A.
Full Name
Cyclin Dependent Kinase 11B
Function
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
Biological Process
Apoptotic process Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cell growth Source: UniProtKB
Regulation of mitotic cell cycle Source: GO_Central
Regulation of mRNA processing Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus
PTM
During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.
Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.
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Anti-CDK11B antibodies

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Mouse Anti-CDK11B Recombinant Antibody (CBYY-C1754) (CBMAB-C3192-YY)

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Target: CDK11B
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig
Clone: CBYY-C1754
Application*: WB, IP, IF, E
Datasheet SDS

Human Recombinant CDK11B protein, GST Tag (V2LY-0526-LY3020)

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Target: CDK11B
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
Datasheet SDS

Rabbit Anti-CDK11B Recombinant Antibody (EG566) (CBMAB-EN685-LY)

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Target: CDK11B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: EG566
Application*: WB, IP
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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