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Rabbit Anti-CDK11B Recombinant Antibody (EG566) (CBMAB-EN685-LY)


See all CDK11B antibodies
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Published Data
CBMAB-EN685-LY-1
Rabbit Anti-CDK11B Recombinant Antibody (EG566) (CBMAB-EN685-LY) in WB
Immunoblot analyses for cell cycle-related proteins following siRNA-mediated down-regulation of CDK11 in melanoma cells. Immunoblot analysis of A375 and WM1366 cell lysates following 30 nM siRNA transfection. SiRNAs transfected are indicated above the blots, proteins detected and time point are indicated on the right side of the blots. ...View More
Ahmed, R. L., Shaughnessy, D. P., Knutson, T. P., Vogel, R. I., Ahmed, K., Kren, B. T., & Trembley, J. H. (2019). CDK11 loss induces cell cycle dysfunction and death of BRAF and NRAS melanoma cells. Pharmaceuticals, 12(2), 50.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-EN685-LY-2
Rabbit Anti-CDK11B Recombinant Antibody (EG566) (CBMAB-EN685-LY) in WB
Western-blotting validation of the selected ART-modulated proteins. ...View More
Chen, X., Wong, Y. K., Lim, T. K., Lim, W. H., Lin, Q., Wang, J., & Hua, Z. (2017). Artesunate activates the intrinsic apoptosis of HCT116 cells through the suppression of fatty acid synthesis and the NF-κB pathway. Molecules, 22(8), 1272.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-EN685-LY-3
Rabbit Anti-CDK11B Recombinant Antibody (EG566) (CBMAB-EN685-LY) in WB
Breast tumor tissues and their adjacent normal tissues were lysed and immunoblotted to determine CDK11p110 expression, with Actin as an internal reference. All the gels were run under the same experimental conditions. Representative example of CDK11p110 expression in breast cancer tissues (C1-C4) and adjacent normal tissues (N1-N4) are shown. ...View More
Zhou, Y., Han, C., Li, D., Yu, Z., Li, F., Li, F., ... & Kan, Q. (2015). Cyclin-dependent kinase 11p110 (CDK11p110) is crucial for human breast cancer cell proliferation and growth. Scientific reports, 5(1), 10433.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Monkey
Clone
EG566
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding Met734 of human PITSLRE/CDK11 protein.
Host Species
Rabbit
Specificity
Human, Mouse, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IP1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 150 mM NaCl, 100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cyclin Dependent Kinase 11B
Introduction
CDK11B (Cyclin Dependent Kinase 11B) is a Protein Coding gene. Diseases associated with CDK11B include Neuroblastoma. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and DNA Damage. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is CDK11A.
Entrez Gene ID
Human984
Mouse12537
UniProt ID
HumanP21127
MouseP24788
Alternative Names
Cyclin Dependent Kinase 11B; Galactosyltransferase-Associated Protein Kinase P58/GTA; Cell Division Cycle 2-Like 1 (PITSLRE Proteins); PITSLRE Serine/Threonine-Protein Kinase CDC2L1; Cell Division Protein Kinase 11B; EC 2.7.11.22; P58 CLK-1; PITSLREA; CDC2L1; CDK11; CLK-1; PK58;
Function
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
Biological Process
Apoptotic process Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cell growth Source: UniProtKB
Regulation of mitotic cell cycle Source: GO_Central
Regulation of mRNA processing Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus
PTM
During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.
Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.
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For research use only. Not intended for any clinical use.

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