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Rabbit Anti-CDKL3 Recombinant Antibody (EG621) (CBMAB-EN748-LY)

The product is antibody recognizes CDKL3. The antibody EG621 immunoassay techniques such as: IHC: 1:50~1:100 ELISA: 1:5000.
See all CDKL3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG621
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 ELISA: 1:5000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CDKL3.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cyclin Dependent Kinase Like 3
Introduction
CDKL3 (Cyclin Dependent Kinase Like 3) is a Protein Coding gene. Diseases associated with CDKL3 include Orofaciodigital Syndrome Vi and Joubert Syndrome 1. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL2.
Entrez Gene ID
51265
UniProt ID
Q5MAI5
Alternative Names
Cyclin Dependent Kinase Like 3; Serine-Threonine Protein Kinase NKIAMRE; Cyclin-Dependent Kinase-Like 3; EC 2.7.11.22; NKIAMRE; Serine/Threonine-Protein Kinase NKIAMRE; EC 2.7.11;
Biological Process
Cellular protein modification process Source: ProtInc
Dendrite extension Source: GO_Central
Negative regulation of axon extension Source: GO_Central
Positive regulation of dendrite morphogenesis Source: GO_Central
Protein phosphorylation Source: GO_Central
Cellular Location
Cytoplasm

Zeng, D. X., Sheng, G. F., Liu, Y. P., Zhang, Y. P., Qian, Z., Li, Z., & Bi, Y. Z. (2021). Cyclin-dependent kinase like 3 promotes triple-negative breast cancer progression via inhibiting the p53 signaling pathway. Neoplasma.

Yan, S., Wei, H., Li, Q., Si, M., Feng, W., & Chen, Z. (2021). CircTP53 promotes colorectal cancer by acting as a miR-876-3p sponge to increase cyclin-dependent kinase-like 3 expression. Cellular Signalling, 78, 109845.

Cui, Y., Yang, Z., Wang, H., Yan, Y., Huang, Q., Gong, Z., ... & Xu, T. (2021). Identification of CDKL3 as a critical regulator in development of glioma through regulating RRM2 and the JNK signaling pathway. Cancer science, 112(8), 3150.

Sun, Q., Zhang, X., Tan, Z., Gu, H., Ding, S., & Ji, Y. (2021). Bone marrow mesenchymal stem cells-secreted exosomal microRNA-205–5p exerts inhibitory effect on the progression of liver cancer through regulating CDKL3. Pathology-Research and Practice, 225, 153549.

He, A., Ma, L., Huang, Y., Zhang, H., Duan, W., Li, Z., ... & Xiang, D. (2020). CDKL3 promotes osteosarcoma progression by activating Akt/PKB. Life science alliance, 3(5).

Zhou, S., Zhang, M., Zhou, C., Wang, W., Yang, H., & Ye, W. (2020). CDKL3 Targets ATG5 to Promote Carcinogenesis of Esophageal Squamous Cell Carcinoma. Frontiers in Oncology, 10, 1602.

Zhang, J., Su, G., Tang, Z., Wang, L., Fu, W., Zhao, S., ... & Xie, X. (2018). Curcumol exerts anticancer effect in cholangiocarcinoma cells via down-regulating CDKL3. Frontiers in physiology, 9, 234.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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