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Mouse Anti-CDKL3 (N-terminus) Recombinant Antibody (CBFYC-1627) (CBMAB-C1687-FY)

This product is mouse antibody that recognizes CDKL3. The antibody CBFYC-1627 can be used for immunoassay techniques such as: WB, IP.
See all CDKL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBFYC-1627
Antibody Isotype
IgG1, k
Application
WB, IP

Basic Information

Immunogen
Fulllength human RPA14 expressed in E. coli
Specificity
Human, Mouse
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
Cyclin Dependent Kinase Like 3
Introduction
CDKL3 (Cyclin Dependent Kinase Like 3) is a Protein Coding gene. Diseases associated with CDKL3 include Orofaciodigital Syndrome Vi and Joubert Syndrome 1. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL2.
Entrez Gene ID
Human51265
Mouse213084
UniProt ID
HumanQ8IVW4
MouseQ8BLF2
Alternative Names
Cyclin Dependent Kinase Like 3; Serine-Threonine Protein Kinase NKIAMRE; Cyclin-Dependent Kinase-Like 3; EC 2.7.11.22; NKIAMRE; Serine/Threonine-Protein Kinase NKIAMRE; EC 2.7.1
Biological Process
Cellular protein modification process Source: ProtInc
Dendrite extension Source: GO_Central
Negative regulation of axon extension Source: GO_Central
Positive regulation of dendrite morphogenesis Source: GO_Central
Protein phosphorylation Source: GO_Central
Cellular Location
Cytoplasm

Zeng, D. X., Sheng, G. F., Liu, Y. P., Zhang, Y. P., Qian, Z., Li, Z., & Bi, Y. Z. (2021). Cyclin-dependent kinase like 3 promotes triple-negative breast cancer progression via inhibiting the p53 signaling pathway. Neoplasma.

Yan, S., Wei, H., Li, Q., Si, M., Feng, W., & Chen, Z. (2021). CircTP53 promotes colorectal cancer by acting as a miR-876-3p sponge to increase cyclin-dependent kinase-like 3 expression. Cellular Signalling, 78, 109845.

Cui, Y., Yang, Z., Wang, H., Yan, Y., Huang, Q., Gong, Z., ... & Xu, T. (2021). Identification of CDKL3 as a critical regulator in development of glioma through regulating RRM2 and the JNK signaling pathway. Cancer science, 112(8), 3150.

Sun, Q., Zhang, X., Tan, Z., Gu, H., Ding, S., & Ji, Y. (2021). Bone marrow mesenchymal stem cells-secreted exosomal microRNA-205–5p exerts inhibitory effect on the progression of liver cancer through regulating CDKL3. Pathology-Research and Practice, 225, 153549.

He, A., Ma, L., Huang, Y., Zhang, H., Duan, W., Li, Z., ... & Xiang, D. (2020). CDKL3 promotes osteosarcoma progression by activating Akt/PKB. Life science alliance, 3(5).

Zhou, S., Zhang, M., Zhou, C., Wang, W., Yang, H., & Ye, W. (2020). CDKL3 Targets ATG5 to Promote Carcinogenesis of Esophageal Squamous Cell Carcinoma. Frontiers in Oncology, 10, 1602.

Zhang, J., Su, G., Tang, Z., Wang, L., Fu, W., Zhao, S., ... & Xie, X. (2018). Curcumol exerts anticancer effect in cholangiocarcinoma cells via down-regulating CDKL3. Frontiers in physiology, 9, 234.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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