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Mouse Anti-CFTR Recombinant Antibody (CF3) (CBMAB-0225CQ)

This product is a mouse antibody that recognizes CFTR. The antibody CF3 can be used for immunoassay techniques such as: Blocking, FC, IF, IHC, IHC-P, IP, WB.
See all CFTR antibodies
Published Data
Fig.1 Immunocolocalization of CFTR with S. Typhimurium SL11344.
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Fig.2 Immunoblot with anti-CFTR antibody and β-actin loading control.
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Fig.3 Confocal microscopy images showing immunolocalization of WT-CFTR or F508del-CFTR protein in CFBE41o-cells.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Chicken, Rat
Clone
CF3
Antibody Isotype
IgM
Application
Blocking, FC, IF, IHC, IHC-P, IP, WB

Basic Information

Specificity
Human, Mouse, Chicken, Rat
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cystic Fibrosis Transmembrane Conductance Regulator
Introduction
The CFTR gene encodes an ATP-binding cassette (ABC) transporter that functions as a low conductance Cl(-)-selective channel gated by cycles of ATP binding and hydrolysis at its nucleotide-binding domains (NBDs) and regulated tightly by an intrinsically disordered protein segment distinguished by multiple consensus phosphorylation sites termed the regulatory domain ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene.
Entrez Gene ID
Human1080
Mouse12638
Rat24255
Chicken100049619
UniProt ID
HumanQ20BH0
MouseP26361
RatP34158
ChickenA0M8U4
Alternative Names
CFTR; cystic fibrosis transmembrane conductance regulator; CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1
Function
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
Biological Process
Chloride transport Source: UniProtKB-KW
Cellular Location
Early endosome membrane; Endosome membrane; Recycling endosome membrane; Apical cell membrane; Cell membrane; Endoplasmic reticulum membrane; Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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