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Hamster Anti-CLCA1 Recombinant Antibody (10.1.1) (CBMAB-0002-CN)

This product is a hamster antibody that recognizes CLCA1 of mouse. The antibody 10.1.1 can be used for immunoassay techniques such as: FC, IF, IHC, IP, WB.
See all CLCA1 antibodies

Summary

Host Animal
Hamster
Specificity
Mouse
Clone
10.1.1
Antibody Isotype
IgG
Application
FC, IF, IHC, IP, WB

Basic Information

Immunogen
Thymic stromal cells
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
chloride channel regulator 1
Introduction
This gene encodes a member of the calcium sensitive chloride conductance protein family. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor.
Entrez Gene ID
23844
UniProt ID
P27816
Alternative Names
gob5; Clca2; Clca3; gob-5
Function
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Biological Process
Calcium ion transport Source: UniProtKB-KW
Cellular response to hypoxia Source: Ensembl
Chloride transport Source: InterPro
Ion transmembrane transport Source: Reactome
Cellular Location
Cell membrane; Extracellular space. Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
PTM
Glycosylated.
The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37- to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.

Lee, H. J., Donati, A., Feliers, D., Sun, Y., Ding, Y., Madesh, M., ... & Kasinath, B. S. (2021). Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging‐related kidney injury. Aging Cell, e13407.

Nyström, E. E., Arike, L., Ehrencrona, E., Hansson, G. C., & Johansson, M. E. (2019). Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2–processing properties. Journal of Biological Chemistry, 294(45), 17075-17089.

Liu, C. L., & Shi, G. P. (2019). Calcium-activated chloride channel regulator 1 (CLCA1): More than a regulator of chloride transport and mucus production. World Allergy Organization Journal, 12(11), 100077.

Hu, D., Ansari, D., Bauden, M., Zhou, Q., & Andersson, R. (2019). The emerging role of calcium-activated chloride channel regulator 1 in cancer. Anticancer research, 39(4), 1661-1666.

Chen, T. J., He, H. L., Shiue, Y. L., Yang, C. C., Lin, L. C., Tian, Y. F., & Chen, S. H. (2018). High chloride channel accessory 1 expression predicts poor prognoses in patients with rectal cancer receiving chemoradiotherapy. International journal of medical sciences, 15(11), 1171.

Hu, D., Ansari, D., Zhou, Q., Sasor, A., Hilmersson, K. S., Bauden, M., ... & Andersson, R. (2018). Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma. BMC cancer, 18(1), 1-6.

Li, X., Hu, W., Zhou, J., Huang, Y., Peng, J., Yuan, Y., ... & Zheng, S. (2017). CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway. Cell Communication and Signaling, 15(1), 1-13.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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