Mouse Anti-CLCA1 Recombinant Antibody (2C10) (CBMAB-C4747-LY)

Name: Mouse Anti-CLCA1 Recombinant Antibody (2C10)
SKU: CBMAB-C4747-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2C10

Application

ELISA, WB

Immunogen

CLCA1 (677 a.a. ~ 776 a.a) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

chloride channel regulator 1

Introduction

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]

Entrez Gene ID

1179

UniProt ID

A8K7I4

Alternative Names

Chloride Channel Accessory 1; Chloride Channel, Calcium Activated, Family Member 1; Calcium-Activated Chloride Channel Family Member 1; Calcium-Activated Chloride Channel Protein 1; Chloride Channel Regulator 1; HCaCC-1; CaCC-1; HCLCA1; CACC1;

Function

May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.

Biological Process

Calcium ion transport Source: UniProtKB-KW
Cellular response to hypoxia Source: Ensembl
Chloride transport Source: InterPro
Ion transmembrane transport Source: Reactome

Cellular Location

Cell membrane; Extracellular space. Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.

PTM

Glycosylated.
The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37- to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.

Lee, H. J., Donati, A., Feliers, D., Sun, Y., Ding, Y., Madesh, M., ... & Kasinath, B. S. (2021). Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging‐related kidney injury. Aging Cell, e13407.

Nyström, E. E., Arike, L., Ehrencrona, E., Hansson, G. C., & Johansson, M. E. (2019). Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2–processing properties. Journal of Biological Chemistry, 294(45), 17075-17089.

Liu, C. L., & Shi, G. P. (2019). Calcium-activated chloride channel regulator 1 (CLCA1): More than a regulator of chloride transport and mucus production. World Allergy Organization Journal, 12(11), 100077.

Hu, D., Ansari, D., Bauden, M., Zhou, Q., & Andersson, R. (2019). The emerging role of calcium-activated chloride channel regulator 1 in cancer. Anticancer research, 39(4), 1661-1666.

Chen, T. J., He, H. L., Shiue, Y. L., Yang, C. C., Lin, L. C., Tian, Y. F., & Chen, S. H. (2018). High chloride channel accessory 1 expression predicts poor prognoses in patients with rectal cancer receiving chemoradiotherapy. International journal of medical sciences, 15(11), 1171.

Hu, D., Ansari, D., Zhou, Q., Sasor, A., Hilmersson, K. S., Bauden, M., ... & Andersson, R. (2018). Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma. BMC cancer, 18(1), 1-6.

Li, X., Hu, W., Zhou, J., Huang, Y., Peng, J., Yuan, Y., ... & Zheng, S. (2017). CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway. Cell Communication and Signaling, 15(1), 1-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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